Active Hexose Correlated Compound and T Cell Response in Hind - Limb - Unloaded BALB/c Mice
Journal Title: International Journal of Surgery and Research (IJSR) - Year 2015, Vol 2, Issue 6
Abstract
Introduction: Microgravity - induced immune dysfunction is a potential risk for infection and cancer in astronauts. Active hexose correlated compound (AHCC), a compound obtained from fermented extract of the mycelia of Basidiomycetes mushrooms, has immunomodulating effects. As a nutritional countermeasure, we examined the effect of AHCC on microgravityinduced immune changes by using a hind-limb unloading (HLU) of mice as a microgravity analog. Methods: BALB/c mice were divided into non-HLU and HLU groups. Each group was further divided into subgroups receiving drinking water containing 0, 0.1, 1, and 10 g/kg/day AHCC. After 7 days of HLU and feeding treatment, the proliferative response of popliteal lymph nodes (PLN) to alloantigen was assessed to evaluate in vivo T cell function. Furthermore, LPS-stimulated inflammatory cytokine and chemokine production in splenocytes was examined. Results: The response of PLN was significantly decreased in the HLU group and AHCC supplementation significantly reversed the response. LPS-stimulated cytokine and chemokine production was increased in the HLU group compared to that in the non- HLU group, and AHCC supplementation tended to increase those levels further. Discussion: AHCC enhances in vivo T cell function in microgravity, suggesting that AHCC supplementation under microgravity may have a beneficial role in maintenance of the immune system.
Authors and Affiliations
Anil D. Kulkarni Kulkarni
Keywords
Related Articles
- EP ID EP210622
- DOI 10.19070/2379- 156X-150007
- Views 125
- Downloads 0
The Use of Point of Care Testing for Monitoring of APTT in Patients Receiving Heparin Infusion
Background: There is a high risk of thromboembolic events among patients undergoing cardiac surgery, and perioperative anticoagulation is sometimes required. The time taken for laboratory based APTT blood sampling result...
Anorectal Malformation with Colonic Duplication and Dual Rectovaginal Fistulae
Anorectal malformations associated with colonic duplications are rare. We report a case of imperforate anus, tubular colorectal duplication, and dual rectovaginal fistulae. This case illustrates the diagnostic challenge...
A Case Series of Laparoscopic Duodenojejunostomy for the Treatment of Pediatric Superior Mesenteric Artery Syndrome
Superior mesenteric artery syndrome (SMAS) is a rare, debilitating clinical condition caused by compression of the third portion of the duodenum by the superior mesenteric artery. Common symptoms include intermittent pos...
Fournier’s Gangrene in Upper Egypt, Case Series of 14 Patients
Objectives: Fournier’s gangrene is a rare but serious necrotizing infection of the skin and subcutaneous tissues affecting mainly the genital, perineal and perianal regions with poor outcome. Multidisciplinary approach e...
Replaced Loss of Upper Eyelid by Frontal Skin Graft
Replaced Loss of Upper Eyelid by Frontal Skin Graft.