Activity of Natural Polyether Ionophores: Monensin and Salinomycin against Clinical [i]Staphylococcus epidermidis[/i] Strains
Journal Title: Polish Journal of Microbiology - Year 2015, Vol 64, Issue 3
Abstract
[i]Staphylococcus epidermidis[/i], a coagulase-negative staphylococcus, is the most important pathogen responsible for chronic nosocomial infections. These bacteria produce extracellular slime and form biofilms on various biotic and abiotic surfaces. Bacterial biofilms are very resistant to standard antimicrobial therapy and difficult to eradicate, so it is important to search for a new more effective anti-biofilm agents, for example in the group of natural substances. The aim of the study was to examine the activity of two ionophores - salinomycin and monensin against clinical [i]S. epidermidis [/i]strains[i], [/i]using MIC/MBC method and biofilm formation inhibition assay. Bacterial strains were tested also for slime production using Congo Red Agar. Both tested ionopore antibiotics showed the highest activity against planktonic bacteria of clinical as well as standard [i]S. epidermidis [/i]strains and effectively inhibited the formation of bacterial biofilm.
Authors and Affiliations
Joanna Stefańska, Karolina Stępień, Adam Huczyński, Stefan Tyski
Keywords
Related Articles
- EP ID EP81159
- DOI -
- Views 84
- Downloads 0
Relationship between ureB Sequence Diversity, Urease Activity and Genotypic Variations of Different Helicobacter pylori Strains in Patients with Gastric Disorders
Association of the severity of[i] Helicobacter pylori [/i]induced diseases with virulence entity of the colonized strains was proven in some studies. Urease has been demonstrated as a potent virulence factor for [i]H. py...
The Effect of Fe[sub]3[/sub]O[sub]4[/sub] Nanoparticles on Survival of Probiotic Bacteria [i]Lactobacillus acidophilus[/i] PCM2499 at Lower pH
This paper presents a description of an experiment in which the survival rate of the probiotic bacteria [i]Lactobacillus acidophilus[/i] PCM2499 was increased only due to the presence of Fe3O4 magnetic nanoparticles...
Investigation of the Actual Causes of Hip Joint Implant Loosening Classified as Aseptic – Analysis of Microbiological Culture Results and Levels of Inflammatory Markers
Loosening of the hip joint prosthesis is considered as one of the most significant postoperative complications in recent years. The laboratory diagnostic procedure used to differentiate periprosthetic infection from...
MALDI-TOF MS Detection of Endophytic Bacteria Associated with Great Nettle (Urtica dioica L.), Grown in Algeria
Any plant with a vascular system has a specific endophytic microflora. The identification of bacteria is essential in plant pathology. Although identification methods are effective, they are costly and time consuming. Th...
Antiviral Resistance of Splenocytes in Aged Mice
We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV)...