Acupuncture preconditioning protects against myocardial ischemia/reperfusion injury mediated apoptosis through miR-214/NCX1 activation: a hypothesis
Journal Title: Traditional Medicine Research - Year 2019, Vol 4, Issue 4
Abstract
Early reperfusion of ischemic cardiac tissue is usually the best option to improve clinical outcome of angina pectoris, especially of acute myocardial infarction. However, myocardial reperfusion may cause an abnormal increase of intracellular Ca2+-mediated cardiomyocyte death and consequent loss of cardiac function, which is referred to myocardial ischemia/reperfusion (I/R) injury. Recently, the microRNA-214 (miR-214)/Na+/Ca2+ exchanger (NCX) 1 co-expression is a key factor in cellular protection against myocardial apoptosis for myocardial I/R injury. Once activated, miR-214/NCX1 axis can inhibit several Ca2+ downstream signaling effectors that mediate cell death simultaneously. Studies have shown that acupuncture preconditioning has a protective effect on myocardial I/R injury, but its mechanism deserves further research. It has been proved that acupuncture preconditioning for ischemic myocardium successfully inhibit multiple Ca2+ handling related microRNAs that mediate cell death pathways, and miR-214 is one of its targets. In terms of clinical practice, coronary heart disease (CHD) patients benefit a lot from this intervention. However, there is barely no study correlating acupuncture preconditioning to the miR-214/NCX1 co-expression in patients with CHD. This review aims to discuss whether there is some evidence to justify a recommendation of acupuncture preconditioning in CHD patients as a non-pharmacological therapeutic method to activate the miR-214/NCX1 co-expression network model.
Authors and Affiliations
Hai-Long Fan, Yu-Lan Ren, Li-Zhen Yang, Fei Wu
Keywords
Related Articles
- EP ID EP45309
- DOI 10.12032/TMR20190306109
- Views 221
- Downloads 0
A broad perspective on COVID-19: a global pandemic and a focus on preventive medicine
Coronavirus 2019 has become a highly infectious disease caused by severe acute respiratory syndrome coronavirus-2, a strain of novel coronavirus, which challenges millions of global healthcare facilities. Coronavirus are...
The role of acidic microenvironment in the tumor aggressive phenotypes and the treatment
Recently, the scammer who advocated "acid constitution" as the source of all diseases was fined 105 million US dollars, and the "acid-base balance" theory he founded was also criticized. Although the "acid constitution"...
Metabonomics/metabolomics analysis technology and its application in quality control of traditional Chinese medicines
This article systematically addresses metabolomics/metabonomics techniques and examples of their use in evaluation of traditional Chinese medicines. It provides a new reference for Chinese medicines and the identificatio...
Computational study of the molecular mechanism of Lonicera japonica organic acids against influenza
1. Molecular docking was applied for determining the potential targets of Lonicera japonica organic acids. 2. Finding relationships between the organic acids and proteins of influenza virus NA, HA, M2 and PB2. 3. Loni...
Traditional Chinese medicine should not be ignored during the development of precision medicine with Chinese characteristics
TCM has been playing an important role in disease treatment for thousands of years. This study presents that it may contribute to the development of precision medicine in China, if the prevention, diagnosis and treatment...