Acute and Sub-chronic Toxicity Studies of Aqueous, Methanol and Chloroform extracts of Alstoniaboonei Stem Bark on albino mice
Journal Title: Saudi Journal of Medicine - Year 2017, Vol 2, Issue 5
Abstract
Abstract:In a preliminary research, the authors reported that solvents extracts of Alstoniaboonei (Egbu) possess strong antimalarial activity against NK-65 Chloroquine sensitive Plasmodium bergheiinfected mice with aqueous extract having the highest decrease in mean percentage parasitaemia. This research is therefore aimed at evaluating the acute and sub-chronic toxicity of solvents extracts of the plant on kidney. The (LD50, oral) was conducted in two phases. In the first phase, oral doses of 10, 100 and 1000 mg/kg body weight of the extracts were administered and mice observed for sign of toxicity and death. In the second phase, 1600, 2900 and 5000 mg/kg body weight of the extracts were administered and signs accompanying toxicity and possible death of animals were also monitored. Sub-chronic toxicity studies were carried out to assess the effect of the solvents extracts on kidney function indices after 28 days of oral administration of the extracts at 150, 250 and 500 mg/kg body weight. The (LD50, oral) of all extracts was found to be greater than 5000mg/kg which is practically non- toxic according to standard scale of toxicity. The result of sub-chronic toxicity study showed a significant increase (P<0.05) in mean levels of creatinine, urea and serum electrolytes in all extracts administered groups in a dose dependent pattern compared to normal control. However, histopathological analysis of the kidney tissues shows no pathological changes between test groups and normal control. Thus, solvents extracts of Alstoniaboonei modifies biochemical parameters (Crea, Urea and Electrolytes) but within the context of duration of this research, no significant pathology was observed in kidney tissues. Alstoniaboonei stem bark should be used with caution. Keywords:Acute toxicity, sub-chronic toxicity, kidney Function Indices and Alstoniaboonei
Authors and Affiliations
A. J. Alhassan, A. A. Imam, M. K. Atiku, M. D. Ezema, I. U. Muhammad, A. Idi, I. Alexander
Keywords
Related Articles
- EP ID EP386833
- DOI -
- Views 109
- Downloads 0
Comparison of Beta Brain Waves in Seeing Famous and Fameless People - A Prestudy
In recent studies, specific neurons were discovered in the brain which is devoted to a single person or object. For example, various pictures of Jennifer Aniston elicited a response in the same specific neuron unit insid...
A Comparative Study of Thoracolumbar Spine Fractures Treated by Conservative Management versus Pedicle Screw Fixation
Spinal trauma is very common in orthopedic practice. There is a debate as to whether the surgical or conservative approach is more effective in the treatment of spine fractures. We in the present study tried to evaluate...
Acute Cytolytic Hepatitis Induced by Allopurinol
Allopurinol is a drug indicated for the treatment of hyperuricemia. Its hepatic toxicity is rare. This is a case report about acute cytolytic hepatitis caused by allopurinol in a 62-year-old.
Congenital Constriction Band Syndrome: A Case Report and Literature Review
Abstract: Congenital constriction band syndrome is a congenital disorder caused by entrapment of parts in fibrous band while in utero. A review of the operating register revealed only two cases in three years. We are pre...
Study of Clinical Profile of Cardiomyopathy at Tertiary Care Centre
Abstract:Breathlessness and Paroxysmal Nocturnal Dyspnoea (PND) is a common cause of emergency visit in our country. Cardiomyopathy is among most common cause of Breathlessness and Paroxysmal Nocturnal Dyspnoea (PND). Th...