Acute and subchronic toxicity studies of Limnophila heterophylla and Michelia champaca
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 3
Abstract
In an attempt to mobilize indigenous healthcare knowledge, acute and sub chronic toxicity studies were performed on the methanol extracts of leaves of Limnophila heterophylla and Michelia champaca. In the acute toxicity study, a single oral dose (2000 mg/kg) of the methanol extracts of leaves of Limnophila heterophylla (MELH) and Michelia champaca (MEMC) was administered independently to rats and observed for 14 days meant for signs of acute toxicity. In sub chronic toxicity study, rats were administered with MELH & MEMC separately (250 and 500 mg/kg) daily for three months. Biochemical and haematological analysis were carried out on blood samples at the end of the treatment. The results showed that administration of 2000 mg/kg of MELH and MEMC to animals did not produce any mortality. In biochemical and haematological analysis, no significant differences between control and test animals was observed. The findings suggested that methanol extracts of Limnophila heterophylla and Michelia champaca were well tolerated both in acute and sub chronic toxicity studies.
Authors and Affiliations
Raja S
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