Acute Anti-inflammatory activity of Eraippu Noi Chooranam on carrageenan induced paw edema in wistar albino rats
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 1
Abstract
The aim of the present study was to explore the probable anti-inflammatory activity of aqueous extract of Eraippu Noi Chooranamusing Carrageenan induced inflammation in wistar rats. The medicinal value of the ingredients of ENC has been mentioned in ancient literature as useful in disorders of inflammation. The anti-inflammatory effect was done by carrageenan induced hind paw edema method using digital plethysmometer. Wistar rats were treated orally with distilled water (as negative control group), 10mg/kg of Diclofenac sodium in normal saline intra peritonially (as standard group) and aqueous extract of ENC (135, 270 and 400 mg/kg) as test group 30 min before 0.1 mL 1% carrageenan injection. Paw volume was measured before and at 0,30 min, 1, 2, 3, 4, 5 and 6th hr after the injection of carrageenan. The results were expressed as the Mean ±SEM and the statistical significance of differences between groups was analyzed by One Way Analysis of Variance (ANOVA) followed by Dunnett’s test. The sub plantar injection of carrageenan caused a time-dependent paw edema in the rats. Oral administration of aqueous extract of ENC(135, 270 and 400 mg/kg) inhibited paw swelling. The maximum inhibition of paw volume was observed at 2 and 3 hr after treatment with ENC at each does but the activity was almost static after 4 hrs. We can conclude from the outcome of the present work that the low dose of ENC exhibits similar effect as comparable to the high dose which shows low dose of ENC itself possess significant anti inflammatory activity.
Authors and Affiliations
1Dr. Amala Hazel . A. M*, 2Dr. Pattarayan. R , 3Dr. Banumathi. V
Keywords
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- EP ID EP550450
- DOI 10.22192/ijcrms.2018.04.01.021
- Views 177
- Downloads 0
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