ACUTE EFFECT OF FLUCONAZOLE, ITRACONAZOLE AND VORICONAZOLE ON BLOOD GLUCOSE IN NORMOGLYCEAMIC & DIABETIC RATS: AN EXPERIMENTAL STUDY
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 1
Abstract
Anti-fungal and antimicrobials are frequently co-prescribed either to manage or treat either the secondary complications or other diseases. Among antifungal drugs Fluconazole, Itraconazole & Voriconazole are most commonly used. The present study was undertaken to further confirm the effect of Voriconazole as well as other antifungal drugs on blood Glucose level. Aim & Objectives: 1. To Study the effect of Fluconazole, Itraconazole & Voriaconazole in Normoglycemic & Diabetic Rats on Blood Glucose. 2. To compare the effects between all drugs. Material & Methodology: Grouping: Animals divided into 8 groups in each group 6 animals. Group 1- 4: Normoglycemic rats, Group 5-8 Diabetic rats (alloxan induced) Group 1,5: received vehicle (Normal saline) Group 2,6: received Fluconazole (18mg/kg BW), Group 3,7 received Itraconazole (18mg/kg BW) Group 4,8 received Voriconazole (18mg/kg BW). The glucose levels were estimated by Glucometer method (Accu-check active) at the interval of 0, ½ hr, 1hrs, 2hrs & 4hrs after drug administration. Results: Effect on blood glucose in Normoglycemic Rats: Voriconazole had a significant hypoglycaemic effect which appeared after 1 hr (‘p’ value= 0.0102) of administration & persisted up to 2 hrs (‘p’ value=0.0001). However effect of Voriconzole was found to be declined after 2 hrs. There was no significant change in blood glucose in normoglycemic rats with Fluconazole & Itraconazole. Effect on blood glucose in Diabetic Rats: (Table 2): Voriconazole had a significant hypoglycaemic effect which appeared after 1 hr (‘p’ value=0.013) of administration & persisted up to 2 hrs (‘p’ value=0.001) in acute studies. However effect of Voriconzole was found to be declined after 2 hrs. There was no significant change in blood glucose in diabetic rats with Fluconazole & Itraconazole treated. Conclusion: Itraconazole, Fluconazole can be safely used in diabetic with fungal infections. Voriconazole should be avoided in diabetics to minimise the further hypoglycaemia.
Authors and Affiliations
Jadhav Amol| Department of Pharmacology, Padmashree Dr. Vithalrao Vikhe Patil Foundation’s Medical College, Ahmednagar, Maharashtra, Corresponding author email: dramoljadhav1@gmail.com, Nayak BB| Department of Pharmacology, Padmashree Dr. Vithalrao Vikhe Patil Foundation’s Medical College, Ahmednagar, Maharashtra, Vakade Kiran P| Department of Pharmacology, Padmashree Dr. Vithalrao Vikhe Patil Foundation’s Medical College, Ahmednagar, Maharashtra, Sanghishetti Vijay Prasad| Department of Pharmacology, Padmashree Dr. Vithalrao Vikhe Patil Foundation’s Medical College, Ahmednagar, Maharashtra, Vijay Kumar AN| Department of Pharmacology, Padmashree Dr. Vithalrao Vikhe Patil Foundation’s Medical College, Ahmednagar, Maharashtra, Vrushali Nibrad| Department of Pharmacology, Padmashree Dr. Vithalrao Vikhe Patil Foundation’s Medical College, Ahmednagar, Maharashtra, Raul AR| Department of Pharmacology, Padmashree Dr. Vithalrao Vikhe Patil Foundation’s Medical College, Ahmednagar, Maharashtra
Keywords
Related Articles
- EP ID EP11360
- DOI 10.5958/2319-5886.2015.00026.0
- Views 251
- Downloads 16
PULMONARY FUNCTION TESTS IN TYPE II DIABETICS IN CORRELATION WITH FASTING BLOOD GLUCOSE
Background & Objectives: Diabetes mellitus (DM) is a significant public health problem worldwide which is associated with hormonal, metabolic and micro vascular abnormalities. The angiopathic complications affect eyes,...
Exploring the effectiveness of obstetrics and gynecology information systems in hospitals of a developing country: A qualitative content analysis
Obstetrics and gynecology information systems are designed to replace paper charts, interact with other clinical wards of hospital, and to better care for patients. This qualitative study was performed to explore the pe...
HEPATITIS B AND C VIRAL INFECTIONS AMONG BLOOD DONORS AT BAHIR DAR, ETHIOPIA
Background: Hepatitis B virus and hepatitis C virus are the major public health problem world wide that affects billions of people. In the study area, there is lack of available information on this issue. Aims: the aim...
AN ETHNOBOTANICAL SURVEY OF MEDICINAL PLANTS USED BY TRADITIONAL HEALERS OF THADVAI, WARANGAL DISTRICT, ANDHRA PRADESH, INDIA
Since ancient times, plants have been used as medicine, foods, Agrochemicals and pharmaceuticals by large number of tribes, rural and urban people. India has more than 300 tribal communities. The tribal region of Andhr...
Comparison of Effectiveness of Reflexology and Abdominal Massage on Constipation among Orthopedic Patients: A single-blind Randomized Controlled Trial
Constipation is one of the most common health problems presenting in patients hospitalized within orthopedic settings. This present study was done with the aim of determining the effect of foot reflexology and abdominal...