Acute Effects of Inspiratory Muscle Training on Pulmonary Arterial Pressure,Cardiac Output and Pulmonary Arterial Saturation Derived Oxygen Cost of Breathing
Journal Title: Chronic Obstructive Pulmonary Disease: Open Access - Year 2017, Vol 2, Issue 1
Abstract
Respiration and respiratory maneuvers affect cardiac output. Inspiratory muscle training (IMT) increases the negative thoracic pressure, which could have an impact on intra-thoracic hemodynamics and thereby influence the cardiac output (CO). The objective of our study was to determine changes in pulmonary arterial (PA) hemodynamics and the CO during IMT in patients with suspected pulmonary hypertension. A new method for measuring the oxygen cost of breathing during IMT was also developed. 22 patients were included in this prospective study. They performed IMT during right heart catheterization. Mixed-venous blood gas analysis was performed before and at the end of IMT to calculate the oxygen cost of breathing. The baseline PA pressure was systolic/diastolic/mean (s/d/m) 41 ± 20/13 ± 20/25 ± 11 mmHg. The CO was 5.3 ± 1.5 l/min. The IMT was set to 2.3 ± 0.6 kPa (23.7 ± 5.7 cmH2O). The PA pressure at the end of IMT was s/d/m 44/10/22 mmHg s/d/m. Though there was a trend towards a lower diastolic pressure, this change was not statistically significant (p=0.06). CO (6.2 ± 1.1 l/min) did not change due to IMT. The mixed-venous hemoglobin oxygen saturation was 71.8 ± 2.3% before IMT, with a significant reduction to 65.8 ± 5.9% (p=0.027) at the end of IMT. IMT as performed in our study neither changed the mean PA pressure nor the CO. Measuring the oxygen cost of breathing is feasible by the method described in our paper.
Authors and Affiliations
Sven Stieglitz, Sandhya Matthes, Christina Priegnitz, Lars Hagmeyer, Winfried Randerath
Keywords
Related Articles
- EP ID EP304119
- DOI 10.21767/2572-5548.100023
- Views 39
- Downloads 0
Relation between Cor Pulmonale Status and Metrics of Six Minute Walk Test in Patients with Chronic Obstructive Pulmonary Disease: A Cross Sectional Study
Background: Cor pulmonale is a complication of chronic obstructive pulmonary disease (COPD). The use of the six minute walk test (6MWT) to discriminate between COPD patients with and without cor pulmonale remains unclear...
Validation of the COPD Assessment Test in Patients with COPD in Iran
Background: Chronic obstructive pulmonary diseases (COPD) is among the most important causes of chronic disease in adulthood. COPD assessment test (CAT) and Saint George Respiratory Questionnaire (SGRQ) are two health re...
Minute lesions of alveolar damages in lungs of patients with stable chronic obstructive pulmonary disease
Objective: To reveal the mechanism underlying recruitment of neutrophils in chronic obstructive pulmonary disease (COPD) lungs and to investigate the role of minute lesions of alveolar damage (MLADs) in emphysema develop...
Individualized Care in COPD: Updated Guidelines from Revised GOLD 2017 Report
Chronic obstructive lung disease (COPD) is a major cause of morbidity and mortality around the world. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) program provides evidence based guidelines to optimi...
Acute Effects of Inspiratory Muscle Training on Pulmonary Arterial Pressure,Cardiac Output and Pulmonary Arterial Saturation Derived Oxygen Cost of Breathing
Respiration and respiratory maneuvers affect cardiac output. Inspiratory muscle training (IMT) increases the negative thoracic pressure, which could have an impact on intra-thoracic hemodynamics and thereby influence the...