Acute hepatitis as a manifestation of Cushing's disease
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2002, Vol 19, Issue 5
Abstract
Clinical manifestations of the pituitary dependent endogenous hypercortisolism syndrome (Cushing’s disease) are related to both the degree and the duration of hypercortisolism. In acute onset severe hypercortisolism (characterized by high concentrations of cortisol), hypertension, edema, hypokalemia, weakness and diabetes mellitus or glucose intolerance constitute the most typical and main clinical features and chemical abnormalities. Clinical presentations arising from the liver usually occur during the disease progression and generally manifest as moderate non-alcoholic steatohepatitis (NASH). Acute hepatitis as the first manifestation of Cushing’s syndrome is very rare and, to the best of our knowledge, has not so far been reported in the literature. We report the case of a 45 year-old male with Cushing’s disease, presenting with arterial hypertension, edema of the lower extremities, hypokalemia, diabetes mellitus and a marked elevation of hepatic enzyme levels, due to NASH, which created difficulties in differential diagnosis. In conclusion, acute hepatitis can be a manifestation of Cushing’s disease and Cushing’s disease shoud be included in the differential diagnosis of acute hepatitis when other clinical manifestations suggest the diagnosis and commoner causes (i.e. viruses) have been excluded.
Authors and Affiliations
V. PAPADIMITROPOULOS, S. DOURAKIS, I. PAPANIKOLAOU, K. PETRAKI
Keywords
Related Articles
- EP ID EP96630
- DOI -
- Views 60
- Downloads 0
A study of hereditary ataxias in the Greek population
OBJECTIVE To study hereditary ataxias in the Greek population, focusing on the prevalence, geographical distribution and phenotypic and genotypic spectrum of Friedreich's ataxia and dominant ataxias, also known as spinoc...
Αtlas injuries
The occipito-atlanto-axis complex consists of the atlas, lying between the occipital condyles and the axis. A variety of daily activities are achieved by the use of this complex. The anatomical location of the atlas make...
Individual and contextual influences of social variables in health outcomes: Τhe impact of social capital <br /> <br />
The term social capital can be traced back to the beginning of the last century and many of its features and their relationship to health were well-established long before the introduction of the term into the academic a...
Evaluation of the quality of health services patient reports
OBJECTIVE The dual aim of this study was, first, to enrich the methods of evaluation regarding the effectiveness of the provision of health services, and secondly, to attempt to assess in an objective way the delivery of...
Modern diagnostic imaging in juvenile idiopathic arthritis
The current strategies of treatment of juvenile idiopathic arthritis (JIA) have achieved a significant reduction or even prevention of structural joint damage and associated functional disability. The trend towards early...