Acute Invasive Fungal Rhino-sinusitis: Clinical, Microbiological and Pathological Diagnosis
Journal Title: Microbiology Research Journal International - Year 2017, Vol 21, Issue 1
Abstract
Background: Acute invasive fungal rhinosinusitis (AIFRS) is a challenging disorder that is diagnosed frequently in immunocompromised patients with very rapid progression. Objective: to estimate the burden of AIFRS in Mansoura University Hospitals and to assess the mycological and clinicopathological profile of the disease. Methods: Specimens were subjected to microbiological and histopathological examinations. Data about demographic characters, underlying diseases, presenting symptoms, signs, surgical interventions, and complications were collected. Results: Twenty-two patients were diagnosed as AIFRS. Patients were 15 males and 7 females with age ranged from 14 to 55 years. The disease was prevalent among immunocompromised patients (100%). Hematological malignancies were the most common underlying conditions (68.18%), The remaining patients had disorders associated with immunosuppression as solid organ transplantation (18.18%) and non-insulin-dependent diabetes mellitus (13.64%). Culture results were positive only in 15 patients (68.18%). Aspergillus species (8/15) were the most common isolated organisms followed by Zygomycetes (7/15). Conclusions: AIFRS continues to present a challenge to the otolaryngologist who must be highly suspicious at risk patient populations. Histopathological examination had high sensitivity. The isolated organisms were Aspergillus species and Rhizopus.
Authors and Affiliations
Shawky Elmorsy, Shirien Amin Rakha, Noha Tharwat Abou El-Khier, Safaa Mohamad EL-Ageery, Nawal S. Gouda, Hoda Saleh
Keywords
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- EP ID EP315990
- DOI 10.9734/MRJI/2017/35241
- Views 95
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