Acute Kidney Injury in a Child with Paroxysmal Cold Haemoglobinuria
Journal Title: Journal of Clinical & Medical Case Reports - Year 2016, Vol 3, Issue 1
Abstract
Paroxysmal cold haemoglobinuria (PCH) is characterised by intravascular haemolysis mediated by the Donath-Landsteiner (D-L) antibody. It accounts for up to forty percent of all cases of autoimmune haemolytic anaemia in children. Acute kidney injury (AKI) in association with PCH, however, is very rare with only two published case reports in the paediatric literature. We report the case of a nine-year-old boy who developed AKI secondary to PCH. Supportive treatment with active warming and strict fluid management was commenced. He required two sessions of haemodialysis and two warmed red cell transfusions. Recovery wascomplete with normal renal profile and haemoglobin at five weeks. At twenty months he remains disease-free. This case adds to the paediatric literature describing AKI in the setting of PCH. Although AKI is a rare complication, the importance of careful monitoring of fluid status and renal function is emphasised in the setting of acute intravascular haemolysis.
Authors and Affiliations
Ben McNaughten
End-Stage Renal Disease and Early-Onset Calciphylaxis: A Case Report
We discuss the presentation of Mr. B, a 51-year-old African American male, diagnosed with End-Stage Renal Disease (ESRD) initiated on hemodialysis 6 months prior to presentation. After starting dialysis, the patient deve...
Ehlers-Danlos Syndrome and Skin Grafting
Ehlers-Danlos syndrome is a heritable connective tissue disorder with an estimated prevalence of one in 10,000 to 25,000 persons [1]. Using clinical phenotype, biochemical and molecular defects, as well as inheritance pa...
Avascular Necrosis of Femoral Head in a 45 year Old Man: A Case Study of an Unnoticed Sickle Cell Disease Patient
Background: Periodic, self-limited episodes of excruciating musculoskeletal pain punctuate the lives of patients with Sickle Cell Disease (SCD) right from childhood. It is very rare for individuals with SCD to be asympto...
An Osteogenesis Imperfecta Type II A in a Female Newborn: A Case Report
Osteogenesis Imperfecta (OI) is characterized primarily by liability to fractures. It is a clinically and genetically heterogeneous connective tissue disorder. Osteogenesis imperfecta type 2 is the lethal type of OI and...
Tricuspid Valve Endocarditis due to Klebsiella Specie in a Non-Intravenous Drug User - A Case Report and Review of Current Literature
Tricuspid valve (TV) endocarditis is known to be predominant among intravenous drug users (IDU) commonly due to staphylococcus species. Isolation of Klebsiella species from a TV endocarditis is an uncommon finding. Endoc...