ACUTE METHEAMOGLOBINEMIA DUE TO NITROBENZENE POISONING: CASE SERIES
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2014, Vol 3, Issue 2
Abstract
Nitrobenzene is a nitrite compound; its toxic effects are due to its ability to convert hemoglobin to methaemoglobin by oxidizing iron. The clinical features of nitrobenzene poisoning vary based on the concentration of methaemoglobin in blood. Immediate identification based on clinical features, odour of the compound with supporting evidence of increased methaemoglobin levels will help in a timely intervention thus preventing fatal outcome. Early haemodynamic and ventilator support along with administration of methylene blue as an antidote has been proved crucial in saving some lives. An acute nitrobenzene poisoning presenting with methaemoglobinemia is becoming quite common in this part of the country. Here authorsreport a series of cases of nitrobenzene poisoning where immediate clinical evaluation, with repeated intravenous methylene blue saved three patients, but two patients presenting late and with heavy exposure could not be saved.
Authors and Affiliations
Harish Kumar S| Assistant Professor, Department of Medicine, Sri Devaraj Urs Medical College, Kolar, Karnataka, IndiaCorresponding author email:drharish21@yahoo.co.in, Ujjawal Kumar| Resident, Department of Medicine, Sri Devaraj Urs Medical College, Kolar, Karnataka, India, Raghavendra Prasad B N| Professor and Head, Department of Medicine, Sri Devaraj Urs Medical College, Kolar, Karnataka, India, Kiran BJ| Resident, Department of Medicine, Sri Devaraj Urs Medical College, Kolar, Karnataka, India, Anil Kumar M| Resident, Department of Medicine, Sri Devaraj Urs Medical College, Kolar, Karnataka, India
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- EP ID EP11201
- DOI 10.5958/j.2319-5886.3.2.096
- Views 324
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