ACUTE-PHASE INFLAMMATORY RESPONSE IN PATIENTS WITH PULMONARY TUBERCULOSIS
Journal Title: Acta Facultatis Medicae Naissensis - Year 2014, Vol 31, Issue 3
Abstract
The main issue in patients with pulmonary tuberculosis (PTB) represents the impossibility of the host immune response to express bactericidal function and the sterilization of lesions depends exclusively on the specific antimicrobial chemotherapy. In order to investigate the value of acute-phase inflammatory response markers in patients with newly confirmed extensive PTB, there was designed a clinical study with 80 patients, of whom 40 had active disease (experimental group), while other 40 had inactive sequellar disease without comorbidity (control group). The examined groups were homogenous with respect to the patient’s general demographic characteristics. In the experimental group, 20.0% of the patients had an initial bacterial infection of the lower respiratory tract, while their average value of acute-phase systemic inflammatory markers was initially, before the antituberculosis treatment, significantly elevated compared to the control group. At the end of the treatment, values of erythrocyte sedimentation rate in the first hour (SE) and serum C-reactive protein (CRP) significantly decreased (SE-p <0.001, CRP-p<0.001), together with the value of the leukocyte count (Le) and serum fibrinogen (Le-p<0.001, fibrinogen-p<0.001). Multivariate linear regression analysis proved a significant correlation between baseline serum fibrinogen level with positive history of contact with active TB patient and initial radiological extent of PTB lung lesions. The values of the acute-phase inflammatory response markers in active PTB have its clinical significance in the assessment of unfavourable course of disease in extensive disseminated form of PTB as well as in the occurrence of complications associated with low respiratory tract bacterial superinfection.
Authors and Affiliations
Milan Radović, Tatjana Pejčić, Ivana Stanković, Lidija Ristić, Zorica Ćirić
Keywords
Related Articles
- EP ID EP152809
- DOI 10.2478/afmnai-2014-0023
- Views 90
- Downloads 0
Staphylococcus aureus: imunopatogeneza i imunitet kod ljudi
Brojni su faktori patogenosti koji omogućavaju visok stepen virulencije mikroorganizmu poput Staphylococcus aureus (S. aureus). Posebno je važno sagledati faktore sposobnosti stalne adaptacije na mehanizme imunskog odg...
The Impact of Disease Activity in Patients with Rheumatoid Arthritis on Metabolic Syndrome and Cardiovascular Risk Assessment
Patients with rheumatoid arthritis (RA) have a 1.5 times higher cardiovascular disease mortality compared to the general population, while the life expectancy of these patients is 5-10 years shorter compared to the gener...
ULOGA HISTEROSKOPIJE U EVALUACIJI BOLESNICA SA ABNORMALNIM KRVARENJEM IZ UTERUSA
Cilj ove studije je definisanje značaja histeroskopije kao dijagnostičke procedure u evaluaciji kavuma uterusa kod bolesnica sa problemom abnormalnog krvarenja iz uterusa. Cilj je, takođe, uporediti histeroskopske sa his...
BIOAVAILABILITY OF HEAVY METALS IN THE SOIL FROM DIFFERENT LOCATIONS OF MEDICINAL HERBS
Medicinal herbs and their mixtures, which are widely used for prevention and treatment of some disease, can also present health risks due to the presence of toxic metals such as Pb and Cd. The application of different ag...
EVALUACIJA ANTROPOMETRIJSKIH INDIKATORA METABOLIČKOG SINDROMA I NJIHOVA POVEZANOST SA METABOLIČKIM FAKTORIMA RIZIKA KOD ZDRAVIH OSOBA U NOVOM BEOGRADU
Osobe sa metaboličkim sindromom (MetSy) imaju dva puta veće šanse da obole od kardiovaskularnih bolesti i preko četiri puta veće šanse da obole od dijabetesa tipa 2 u odnosu na osobe bez metaboličkog sindroma. Obim struk...