Acute Phase Reactant Correlates and Erythrocyte Sedimentation Rate Among Type 2 Diabetes Mellitus Patients in Yenagoa, Nigeria
Journal Title: IOSR Journal of Nursing and health Science - Year 2019, Vol 7, Issue 1
Abstract
The South-South Region of Nigeria had the highest pooled prevalence of 8.5% of type 2 diabetes mellitus (T2DM) in Nigeria between 1985 and 2016. This signals the need for the use of additional markers, as tools for the diagnosis of the disease in order to monitor and manage therapy. This study was aimed at evaluating the acute phase reactant correlates among T2DM patients in Yenagoa, a city in the region. 123 subjects (80 T2DM and 43 control) were enrolled in the study based on a cross-sectional design. Venous blood samples were collected from all subjects and tested for fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), C-reactive protein (CRP), albumin, and erythrocyte sedimentation rate (ESR). Data was analyzed using Statistical Package for Social Sciences (SPSS) version 20, and was grouped into ESR, CRP, Albumin, FPG and HbA1c, for each of T2DM and nondiabetic control subjects. Difference in measured parameters between test and control were compared using the independent T-test. Pearson correlation coefficient was determined for associations between groups. All regression graphs were made using GraphPad Prism 5. An error probability (p)-value โค .05 was considered significant. Results showed significant difference in all studied parameters between T2DM patients and control (t > 2.00, p < .01). Strong significant correlation was observed between CRP and ESR (r = 0.96, p = .01) expressed by the regression line: ๐ธ๐๐ = 10.72 +1.83 ร ๐ถ๐ ๐ (R2 = 0.92) of T2DM subjects. Strong significant correlation was also observed between HbA1c and FPG with linearity as ๐ป๐๐ด1๐ = 3.47 + 0.37 ร ๐น๐๐บ (R2 = 0.87, r = 0.93, and p = .01), and albumin showed a direct relationship with FPG among these patients. We had demonstrated significant difference in levels CRP, ESR, and albumin concentration between T2DM patients and apparently healthy control subjects, we further conclude that the ESR can be used as a surrogate of CRP in conjunction with the FPG and 2h-PG in diagnosis of T2DM in our resource limiting setting
Authors and Affiliations
Teddy Charles Adias, Evelyn M. Eze, Diweni Pere Dick
Keywords
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