Acute Renal Failure Caused by Leptospirosis
Journal Title: Medicine in Evolution - Year 2017, Vol 0, Issue 4
Abstract
Leptospirosis is the most important zoonosis worldwide. Patients are usually young. There are multiple factors involved in the renal lesions caused by leptospirosis, including the direct nephrotoxic action of leptospirae, hyperbilirubinaemia, rhabdomyolysis and hypovolemia. The most important lesions are acute interstitial nephritis and acute tubular necrosis. Leptospirosis-induced ARF is usually non-oliguric and hypokalemic. Functional abnormalities are preceded by decreased glomerular filtration rate (GFR) which might explain the high frequency of hypokalemia. Antibiotic treatment is effective during early as well as during late and/or severe stages of the disease. For critical leptospirosis patients the following measures are recommended: early daily hemodialysis; reducing the perfusate volume (due to the risk of pulmonary haemorrhage), and applying lung protective therapeutic strategies. The mortality in leptospirosis associated ARF varies between 1 and 22%.
Authors and Affiliations
Librimir C. , Olariu N. , Romoşan I.
Keywords
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