acuum Therapy of Diabetic Soft Tissue Wounds: the Impact on the Matrix Metalloproteinase Activity
Journal Title: Міжнародний ендокринологічний журнал - Year 2016, Vol 1, Issue 73
Abstract
The objective was to investigate the effect of vacuum therapy on the main stages of the healing of purulent wounds of soft tissues in patients with diabetes mellitus, the degree of microbial contamination of wounds and the activity of matrix metalloproteinases (MMP) in the tissues of wound surface. The results of treatment and examination of 48 patients with chronic diabetic wounds of soft tissues were analyzed. In 26 patients (study group), vacuum therapy of wounds was used in the treatment complex. During healing process, microbiological and cytological parameters were determined. MMP activity in the tissues of wound surface of patients from the control and study groups was monitored by the method of gelatine zymography at the various stages of healing. It was found that in patients of the main group, wound purification from necrotic material and microorganisms occurred 5.2 ± 1.5 days earlier than in patients of the control group. Moreover, in the tissues of wound surface of patients from study group, a statistically significant (p < 0.05) decrease in MMP activity was observed, its value on the 5th and 10th days of treatment was respectively 68 and 45 % of the initial level. In the wounds of patients with diabetes mellitus who underwent traditional medical treatment, collagenase activity remained consistently high throughout the period of observation. So, together with antimicrobial and anti-inflammatory effects, the normalization of proteolytic processes in the wound bed can be one of the key mechanisms of high therapeutic effectiveness of VAC-therapy.
Authors and Affiliations
O. M. Petrenko, B. H. Bezrodnyi, A. O. Tykhomyrov
Keywords
Related Articles
- EP ID EP207080
- DOI -
- Views 60
- Downloads 0
Cognitive Disorders in Young Patients with Diabetes Mellitus Type 1
The article presents the data on the assessment of cognitive function in young patients with diabetes type 1 and identification of possible risk factors. The presence of hypoglycemia, diabetic retinopathy has an impact o...
Primary Adrenal Insufficiency: Diagnosis and Management (According to the 17th European Congress of Endocrinology, Dublin, Ireland 16–20 May, 2015)
Primary adrenal insufficiency (PAI, Addison’s disease) — treatable disease, remains potentially lethal. PAI is often detected in the state of adrenal crisis, and timely emergency treatment can prevent the death. To minim...
Influence of nutrient correction on adiponectin circulating level and cardiovascular risk factors in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease
Aim — to evaluate the influence of dietary recommendations on adiponectin circulating level and haemodynamic characteristics in patients with type 2 diabetes mellitus (DM) and non-alcoholic fatty liver disease. Materials...
Male factor of sterility: algorithm of laboratory diagnosis of the causes
Timely diagnosis of the causes of infertility is the key to the effectiveness of treatment. Given that half of the causes of this condition accounts for male factor, it is important to conduct a comprehensive study to id...
Treatment of Hypothyroidism according to Modern Clinical Guidelines
The most important aspects of hypothyroidism treatment in accordance with the latest international guidelines developed from evidence-based medicine are given in the article. Approaches to levothyroxine therapy in certai...