Adenovirus Infection in Adults: Research of the Reactive Response of Polymorphonuclear Neutrophils
Journal Title: Актуальна інфектологія - Year 2016, Vol 4, Issue 13
Abstract
Background. The ratio of adenovirus disease in the structure of acute respiratory viral infections is substantial, and this group of infections annually makes up to 30 % of general infectious morbidity rate. Today, the peculiarities of heterospecific anti-infectious defense are understudied in patients with adenovirus infection. The aim: to study the reactive response of polimorphonuclear granulocytes of the peripheral blood in adult patients with adenovirus infection. Materials and methods. This case-control study involved 37 young volunteers with the signs of acute respiratory viral infection in the moment of appeal to practitioner (based on the criteria of unified protocol). We have analyzed the absolute and relative amounts of basic populations of immunocompetent cells of the peripheral blood, conducted the calculation of immune-haematological indexes characterizing the reactive response of basic cells of heterospecific immunity. Results. An inflammatory process is associated with the increase in the absolute amount of leucocytes by 19.76 %, band neutrophils — by 2.18 times; lymphocytes — by 30.30 % and monocytes — by 48.15 %. The increase in the reactivity of neutrophilic granulocytes by 83.92 % was detected that indicates the activation of these cells by the system of cytokines in heterospecific anti-infectious defense, and that is why its general activity increases by 12.62 %. Conclusions. The above mentioned testifies the forming of different types of immune response to adenovirus antigens. A specific immune response is formed later, that is confirmed by the decrease in the index of immunological reactivity of patients’ body by 14.86 %. Methodology for the estimation of the reactive response of neutrophils can be used in practical work of doctors for early prognostication of possible changes in the system of anti-infectious defense of patients’ body.
Authors and Affiliations
A. S. Sidorchuk
Keywords
Related Articles
- EP ID EP209694
- DOI 10.22141/2312-413x.4.13.2016.91457
- Views 108
- Downloads 0
Aspects of treatment of lower respiratory tract infections in terms of clinical guidelines of different countries (bronchiolitis, bronchitis, community-acquired pneumonia)
According to the international protocols, the treatment of lower respiratory tract infections has its own characteristics in different countries. In general, only oxygen therapy and proper hydration have sufficient evide...
Treatment Success in Patients with Drug-Resistant Pulmonary Tuberculosis in Cavitation of S6 of Lungs and Concomitant Endobronchial Pathology Using Isoniazid-Hydroxymethylquinoxalinedioxyde in the Comprehensive Treatment
Introduction. Improving the efficiency of treatment of patients with drug-resistant pulmonary tuberculosis in cases of cavitation in the S6 of lungs and concomitant endobronchial pathology. Objective of the study: to exa...
Features of Oropharyngeal Microbiota in Children with Bronchial Asthma and Acute Respiratory Іnfection
The paper deals with the comparative analysis of composition of colonizing microflora in children with bronchial asthma (BA) and acute respiratory infection (ARI). The constant oropharyngeal biotopes in children with ARI...
Peculiarities of the clinical picture of meningitis in children of the first three years of life according to the data of Kyiv Municipal Children’s Clinical Infectious Diseases Hospital in 2010–2015
A retrospective analysis was conducted of 290 case histories in children hospitalized in Kyiv Municipal Children’s Clinical Infectious Diseases Hospital in 2010–2015 with the diagnosis of meningitis. Among them — 73 case...
Experience of Bacillus subtilis Application under Antibacterial Therapy In Children
The antibiotic-associated diarrhea remains an actual problem in medicine. In our research the antibiotic-associated diarrhea was observed in 10 % of patients. Antibiotics (cephalosporins of the 3rd generation) cause dysb...