Adiponectin Gene Polymorphism SNP +45 T/G in Type 2 Diabetic Patients in Assam, India
Journal Title: International Journal for Research in Applied Science and Engineering Technology (IJRASET) - Year 2016, Vol 4, Issue 3
Abstract
Background: Adiponectin SNPs gene have been associated with BMI, insulin sensitivity and type 2 diabetes, reportedly. In this Case study we investigate Adiponectin SNP gene +45*T/G (rs2242766) in type 2 diabetes and Healthy control in Northeast India.Methods: Sample collected from Diabetic patients that visited the diabetes clinic . healthy control group were Volunteers students of Gauhati University. PCR-RFLP method. Is used to analysis the Adiponectin gene polymorphism. obese diabetic patients (n: 80), non-obese diabetic patients (n:72).Healthy controls group (n:70). Results: Frequency of wild genotype (TT) was 62.5% in non-obese diabetic Cases and 78% in control group, that was significant (P=0.02). The allele T and G frequencies were significant in non-obese diabetic. The frequency of allele G in non-obese diabetic Cases was increased (20.1%) in compared to controls (12%) (P=0.04 ) Conclusion: This Cases study we found TG and GG alleles of Adiponectin SNP +45*T/G are risk factors for development of diabetes mellitus . This effect is independent from BMI and obesity.
Authors and Affiliations
Morteza Kordafshari, Marzieh Kordafsharin, Manab Deka, Majid Khandouzi
Keywords
Related Articles
- EP ID EP21697
- DOI -
- Views 203
- Downloads 3
A Method for Compression of Solar Image using Integer Wavelet Transform
Compression is becoming a very important method for reducing the redundancy in the images. The use of larger DWT (discrete wavelet transform) basis functions or wavelet filters produced distortion in the reconstructed i...
Novel Approach to Crosstalk Avoidance in RLC Modelled Interconnects Using Bus Encoder
In this paper, we have proposed efficient bus encoder for crosstalk avoidance in RLC modelled interconnects. In past years many encoding methods have been proposed which dealt with only RC modelled VLSI inter-connects.D...
Advancement in Material Science
Material science is a branch of science with a myriad of disciplines, which encompass the investigation and improvement of novel robust materials with the desired physical and chemical properties. Today material science...
Computational analysis of intensive and extensive properties of Nano fluids
A colloidal mixture of Nano-sized (<100 nm) particles in a base fluid called Nano-fluid, which is the new era of heat exchange fluid for different high temperature exchange applications where transport attributes are co...
Efficiency Enhancement in a Pre-Bunched Cerenkov Free Electron Laser
An electron beam passing through a slow wave structure is unstable to an electromagnetic perturbation whose phase velocity equals the velocity of the beam. This phenomenon of cerenkov emission is the basis of all slow w...