Adiponectin Gene Polymorphism SNP +45 T/G in Type 2 Diabetic Patients in Assam, India
Journal Title: International Journal for Research in Applied Science and Engineering Technology (IJRASET) - Year 2016, Vol 4, Issue 3
Abstract
Background: Adiponectin SNPs gene have been associated with BMI, insulin sensitivity and type 2 diabetes, reportedly. In this Case study we investigate Adiponectin SNP gene +45*T/G (rs2242766) in type 2 diabetes and Healthy control in Northeast India.Methods: Sample collected from Diabetic patients that visited the diabetes clinic . healthy control group were Volunteers students of Gauhati University. PCR-RFLP method. Is used to analysis the Adiponectin gene polymorphism. obese diabetic patients (n: 80), non-obese diabetic patients (n:72).Healthy controls group (n:70). Results: Frequency of wild genotype (TT) was 62.5% in non-obese diabetic Cases and 78% in control group, that was significant (P=0.02). The allele T and G frequencies were significant in non-obese diabetic. The frequency of allele G in non-obese diabetic Cases was increased (20.1%) in compared to controls (12%) (P=0.04 ) Conclusion: This Cases study we found TG and GG alleles of Adiponectin SNP +45*T/G are risk factors for development of diabetes mellitus . This effect is independent from BMI and obesity.
Authors and Affiliations
Morteza Kordafshari, Marzieh Kordafsharin, Manab Deka, Majid Khandouzi
Keywords
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