Adjuvant Chemotherapy in Elderly Patients with Early-stage Non-small Cell Lung Cancer
Journal Title: Bezmiâlem Science - Year 2019, Vol 7, Issue 4
Abstract
Objective: Early-stage non-small cell lung cancer (NSCLC) constitutes approximately 25-30% of newly diagnosed lung cancers. Elderly patients with NSCLC have generallly been underrepresented in clinical studies. We explored adjuvant chemotherapy results in patients ≥65 years with early-stage NSCLC. Methods: The medical records of 111 elderly patients with early-stage NSCLC were reviewed retrospectively. Collected data included demographic information, clinical assessments and information on treatment. Survival was estimated using the Kaplan-Meier method and prognostic factors were evaluated with log-rank and Cox regression tests. Results: The median disease-free survival (DFS) was 22.6 months. In univariate analysis, significant association between stage, performance score (PS), adjuvant chemotherapy and DFS was detected (p<0.05). Stage, PS and adjuvant chemotherapy were found to have significant effects on overall survival (OS) (p<0.05). The median survival for the entire group was 41.6 months. Multivariate analysis showed that stage, PS and adjuvant chemotherapy affected both DFS and OS. Conclusion: Survival of elderly patients with early-stage NSCLC was significantly influenced by stage, PS and adjuvant chemotherapy. These factors, rather than age, should be considered in the treatment planning for elderly patients with NSCLC.
Authors and Affiliations
Umut KEFELİ, Samet KAYMAZ, Dinçer AYDIN, Deniz IŞIK, Devrim ÇABUK, Alper SONKAYA, Özgür AÇIKGÖZ, Ulaş IŞIK, Ercan ÖZDEN, Kazım UYGUN
Keywords
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