Adjuvant Chemotherapy in Elderly Patients with Early-stage Non-small Cell Lung Cancer
Journal Title: Bezmiâlem Science - Year 2019, Vol 7, Issue 4
Abstract
Objective: Early-stage non-small cell lung cancer (NSCLC) constitutes approximately 25-30% of newly diagnosed lung cancers. Elderly patients with NSCLC have generallly been underrepresented in clinical studies. We explored adjuvant chemotherapy results in patients ≥65 years with early-stage NSCLC. Methods: The medical records of 111 elderly patients with early-stage NSCLC were reviewed retrospectively. Collected data included demographic information, clinical assessments and information on treatment. Survival was estimated using the Kaplan-Meier method and prognostic factors were evaluated with log-rank and Cox regression tests. Results: The median disease-free survival (DFS) was 22.6 months. In univariate analysis, significant association between stage, performance score (PS), adjuvant chemotherapy and DFS was detected (p<0.05). Stage, PS and adjuvant chemotherapy were found to have significant effects on overall survival (OS) (p<0.05). The median survival for the entire group was 41.6 months. Multivariate analysis showed that stage, PS and adjuvant chemotherapy affected both DFS and OS. Conclusion: Survival of elderly patients with early-stage NSCLC was significantly influenced by stage, PS and adjuvant chemotherapy. These factors, rather than age, should be considered in the treatment planning for elderly patients with NSCLC.
Authors and Affiliations
Umut KEFELİ, Samet KAYMAZ, Dinçer AYDIN, Deniz IŞIK, Devrim ÇABUK, Alper SONKAYA, Özgür AÇIKGÖZ, Ulaş IŞIK, Ercan ÖZDEN, Kazım UYGUN
The Protective Effects of Long-term Probiotic Application on Experimental Sepsis-dependent Inflammation Process
Objective: Probiotics are defined as live microorganisms that provide beneficial effects on the host when applied in appropriate amounts. The immun-modulatory effects of some probiotics are one of these. We aimed to inve...
A CADASIL Case Presenting with Progressive Bulbar Palsy Caused by Acute Simultaneous Multiple Subcortical Infarcts
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an adult-onset inherited small vessel disease of the brain caused by NOTCH3 mutations. Clinical characteristics of C...
Granulomatosis Polyangiitis Case that Mimics Henoch-schönlein Purpura
Granulomatosis polyangiitis (GPA) is a systemic, necrotizing, granulomatous, antineutrophil cytoplasmic antibody (ANCA) -associated vasculitis that affects small and medium arteries, mainly affecting the upper and lower...
Abdominal Paragangliomas: A Single Center Experience
Objective: Paragangliomas are rare tumors arising from extra-adrenal chromaffin tissue, which are widely distributed near or within the autonomic nervous system in the retroperitoneal sites and in the sympathetic ganglia...
Current Approaches in Premenstrual Syndrome Management
Premenstrual syndrome (PMS) is a health problem that occurs with physical and psychological symptoms presenting about five days before menstruation, end within a few days after the onset of menstruation. The most common...