Adrenaline Induced Elevated Blood Pressure in Wistar Rats is not Reversed by Oral Administration of Archachatina marginata Hemolymph
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 7, Issue 4
Abstract
Background: The increasing incidence of high blood pressure, its complications and associated fatalities has led to an upsurge in the use of alternate forms of medicaments in its management. The oral ingestion of the hemolymph of Archachatina marginata is commonly used as an antihypertensive by the Yoruba people of South West Nigeria. This study investigated the effect of oral administration of Archachatina hemolymph on normotensive and adrenaline induced hypertensive wistar rats. Methods: The hemolymph of Archachatina marginata was orally administered at doses of 22.8 and 45.6 mg/kg body weight to normotensive and adrenaline induced hypertensive rats for 7 days. Blood pressure parameters were measured via a polygraph. Histopathological assessment of the heart tissue was conducted. Data gathering and analysis were done in 2014 (February – August). Results: In this study, the orally administered hemolymph had no significant (p˂0.05) lowering effect on the systolic/ diastolic pressure, pulse pressure, mean arterial pressure or heart rate of either the normotensive or adrenaline induced hypertensive rats. Histopathological assessment of the cross section of the heart tissues shows the hemolymph had no adverse effect on the examined cross section of the heart tissue. Conclusion: Based on the data from this study, there is no justifiable reason for the use of the hemolymph of Archachatina marginata as a antihypertensive.
Authors and Affiliations
Anthony B. Ojekale, Ugo Agbafor, Adedoja D. Wusu, Peter I. Jewo, Jamiu A. Oguntola
Keywords
Related Articles
- EP ID EP347849
- DOI 10.9734/BJMMR/2015/15674
- Views 76
- Downloads 0
A Comparative Study to Evaluate the Interplay of Lipoprotein (a) With Traditional Lipid Parameters in Overt and Subclinical Hypothyroidism
Aims: In conjunction with triglyceride (TG) and HDLc, changes in the Lp (a) level in hypothyroidism have shown variable results. In the present study we made an effort to evaluate the role of Lp(a) as cardiovascular risk...
The FITT Principle in Individuals with Type 2 Diabetes: From Cellular Adaptations to Individualized Exercise Prescription
Diabetes mellitus is a complex disease that affects millions of people worldwide. Type 2 diabetes (T2DM) arises from a combination of genetic susceptibility and environmental factors, including physical inactivity and po...
CYP17, CYP19, and NQO1 Genetic Polymorphisms and Breast Cancer Susceptibility in Young Women in Brazil
Aims: Breast cancer is the most common cancer in women worldwide, being exposure to estrogens the acknowledged main risk factor. CYP17, CYP19 and NQO1 are enzymes involved in the estrogen metabolism, so their polymorphis...
ASA Physical Status Score as a Predictive Tool of Mortality in Emergency Postoperative Abdominal Injuries in the ICU
Background: The factors affecting the pattern and outcome of management of postoperative abdominal injuries in the intensive care unit of University of Uyo Teaching Hospital has never been investigated. This is especiall...
Seroprevalences and Associated Factors of Viral Infections (HIV, Hepatitis B and C) among Pregnant Women Attending Antenatal Care at the Yaoundé Central Hospital
Aims: A viral infection is a proliferation of a harmful virus inside the body. HIV infection, viral hepatitis B (HBV) and C (HCV) constitute a public health problem. They affect millions of people worldwide and particula...