Adsorptive Leukocytapheresis in Inflammatory Bowel Diseases: Our Preliminary Results are Encouraging
Journal Title: Turkish Journal of Hematology - Year 2013, Vol 30, Issue 2
Abstract
To the Editor, Infl ammatory bowel disease (IBD), consisting of ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic recurrent disorder with unclear etiology. A close relation to autoimmune status featured by antibodies against colonic epithelial cells was suggested in light of recent studies [1]. Although 5-aminosalicylates and corticosteroids are frequently used in treatment, the management of both conditions is far from being fully satisfactory [2]. Thus, many biological treatment methods, like targeting cytokines involved in intestinal infl ammation, have been developed in the last decade with various results in terms of effi cacy and safety. One of them is cytapheresis, which aims to suppress and reduce impaired immune responses in the diseased intestine by removing circulating activated leukocytes, especially granulocytes, which have been shown to cause intestinal crypt abscess.
Authors and Affiliations
Murat Törüner, Selami Toprak, Kiraz Mızrak, Yasin Yıldırım, Meltem Bay, Erol Ayyıldız, Osman İlhan
Keywords
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- EP ID EP163414
- DOI 10.4274/Tjh.2012.0186
- Views 78
- Downloads 0
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