Advanced Age and Mild Thyrotoxicosis are Associated with Nodular Goiter in Graves Disease
Journal Title: Turkish Journal of Endocrinology and Metabolism - Year 2009, Vol 13, Issue 1
Abstract
Objective: The primary goal of this study is to evaluate predictors of nodular goiter in Graves Disease (GD). Materials and Methods: A total of 202 consecutive patients (mean age: 45; 145 female, 57 male) were enrolled. All patients were treated with antithyroid drugs as initial therapy. TSH, FT3, FT4, TRAb, ATPO, and ATG were measured. Radioactive iodine uptake and thyroid ultrasonography were performed, and thyroid volume and nodule diameter were assessed. Ultrasound-guided fine needle aspiration was performed on thyroid nodules ≥8mm. Results: Diffuse goiter was detected in 51% of patients. Solitary nodules were detected in 16%, and multi-nodular disease in 33%. Mean nodule diameter was 8.82 mm. Nodular disease was slightly more common in women (p=0.063). Patients with nodular GD were older (p=0.004), had lower levels of FT3 (p=0.016) and TRAB (p=0.002) when compared with subjects with diffuse GD. Age (OR:6.867) was the independent variable predicting nodular GD. Conclusion: Increased prevalence of nodules was associated with advanced age and milder thyrotoxicosis. Apoptosis of thyroid follicular cells due to excess iodine might interfere with nodule formation, and lead to diffuse goiter in severe thyrotoxicosis. Because of increased rate if malignancy in GD, comprehensive evaluation of thyroid nodules of any size is mandatory. Turk Jem 2009; 13: 1-4
Authors and Affiliations
Serkan Yener, Nergiz Bayrakçı, Barış Akıncı, Tevfik Demir, Ali Sevinç, Özhan Özdoğan, Tülay Canda, Abdurrahman Çömlekçi, Sena Yeşil
Keywords
Related Articles
- EP ID EP83205
- DOI -
- Views 131
- Downloads 0
Association Between Pro12Ala Polymorphism of Peroxisome Proliferator- Activated Receptor Gamma (PPARγ) and Components of Metabolic Syndrome
Objective: Metabolic syndrome is a highly prevalent complex disorder characterized by abdominal obesity, insulin resistance, dyslipidemia and hypertension. It occurs as a result of the interaction between genetic suscept...
Bell’s Palsy as an Unfavorable Effect of Growth Hormone Therapy in a Pediatric Patient with Turner Syndrome
Bell’s palsy is defined as a lower motor neuron facial palsy of acute onset unaccompanied by evidence of an aural, a neurological or a local cause. Bell’s palsy is an uncommon cause of facial palsy in children under 10 y...
Tuberculosis of the Thyroid Gland: An Uncommon Cause of Thyroid Nodules
We present the case of a 33-year-old woman with tuberculosis of the thyroid. She presented with a thyroid mass, weakness and palpitation for two years.The diagnosis was established on histological examination after thyro...
A Testicular Regression Syndrome Presenting with Feminisation
Testicular regression syndrome is a kind of genital abnormality associated with cessation of testicular function. In the patients with 46 XY karyotype, genital elements are absent, and development of genital duct, urogen...
Graves Hastalarında Tiroid Nodülü Varlığı İleri Yaş ve Ilımlı Tirotoksikoz ile İlişkilidir
Amaç: Bu çalışmanın birincil amacı Graves Hastalığı’ndaki (GH) nodüler guatr belirleyicilerinin ortaya konmasıdır. Gereç ve Yöntemler: Çalışmaya 202 ardışık hasta dahil edildi (ortalama yaş: 45, 145 kadın). Tüm hastalar...