Abstract

Aim: The aim of the study was to determine gingival crevicular fluid (GCF) levels of advanced oxidation protein product (AOPP) and monocyte chemoattractant protein (MCP)-1 in subjects with periodontal disease and health. Materials and Methods: A total of 75 non-smokers, including 25 participants with chronic periodontitis (CP), 25 participants with gingivitis (G) and 25 participants with periodontally healthy (H) were included into the present study. The probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded. The GCF samples from 4 sites in each individual were collected and GCF AOPP and MCP-1 levels were determined by enzyme-linked immunosorbent assay method. Results: GCF AOPP and MCP-1 levels were the lowest in the H group; followed by the G group and the highest in the CP group. These differences were statistically significant between G and H groups and between the CP and the other groups (p <.05). A statistically positive correlation was detected between GCF AOPP and MCP-1 levels. Conclusion: GCF AOPP and MCP-1 levels might play a considerable role during periodontal inflammation and an elevated GCF AOPP and MCP-1 levels are suggested as a potential biomarker for periodontal diseases.

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