Advances in Microscopy-A Review
Journal Title: Voyager - Year 2017, Vol 0, Issue 1
Abstract
Biological microscopy has undergone a revolution in last two decades. Light microscopy is a mainstay of modern molecular, cell and developmental biology laboratories and spans applications in basic research, preclinical and recently even clinical domains. Electron microscopy is also growing with various changes. Rapid developments at all levels of microscopy experiments – from improvements in sample labelling, contrast, illumination, resolution, signal detection and data processing have all occurred and there is every reason to expect that these advances will simply continue. Applications for these new imaging methodologies are also growing. Combining these technical advances with robotics has resulted in automated microscopes suitable for screening small molecule libraries for drug discovery and recording cell phenotypes that result from systematic gene knockdown by RNA interference or tissue phenotypes caused by diseases. Present review summarizes the historical developments in the microscopy technique. It also highlights the advancements in the technique and its myriad applications.
Authors and Affiliations
Neetu Nimesh, Deepali Joon, Manoj Nimesh
Keywords
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