Advances in research on Zika virus
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2017, Vol 10, Issue 4
Abstract
Zika virus (ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight. Clinical manifestations are fever, joint pain or rash and conjunctivitis. Emergence of ZIKV started with a first outbreak in the Pacific area in 2007, a second large outbreak occurred in the Pacific in 2013/2014 and subsequently the virus spread in other Pacific islands. Threat of explosive global pandemic and severe clinical complications linked with the more immediate and recurrent epidemics necessitate the development of an effective vaccine. Several vaccine platforms such as DNA vaccine, recombinant subunit vaccine, ZIKV purified inactivated vaccine, and chimeric vaccines have shown potent efficacy in vitro and in vivo trials. Moreover, number of drugs such as Sofosbuvir, BCX4450, NITD008 and 7-DMA are ready to enter phase I clinical trial because of proven anti-ZIKV activity. Monoclonal based antibodies offer promise as an intervention effective for use in pregnant women. In this review, we describe the advances in research on ZIKV such as research strategies for the development of antiviral drugs & vaccines, molecular evolution, epidemiology emergence, neurological complications and other teratogenic outcomes as well as pathogenesis.
Authors and Affiliations
Muhammad Idrees
Temperature and development of Zika virus infection: An Indonesian case
World Health Organization declared that Zika virus is an international health issue [1,2]. Zika virus infection is a health issue occurring in Asia [3] and transmitted through mosquito bites [4], Aedes aegypti [5]. As th...
Novel PCR primers to diagnose visceral leishmaniasis using peripheral blood, spleen or bone marrow aspirates
Objective: To establish a suitable method of diagnosis of visceral leishmaniasis (VL) using peripheral blood, spleen or bone marrow aspirates. Methods: Peripheral blood, bone marrow and spleen aspirate samples were colle...
Recombinant expression and purification of functional vascular endothelial growth factor-121 in the baculovirus expression system
Objective: To express human vascular endothelial growth factor121 (VEGF121) in insect cells. Methods: A gene construct containing VEGF was cloned in the pFastBac-HTA vector, followed by transformation in DH10BAC. The rec...
Prediction of promiscuous T cell epitopes in RNA dependent RNA polymerase of Chikungunya virus
Objective: To explore RNA dependent RNA polymerase of Chikungunya virus (CHIKV) and develop T cell based epitopes with high antigenicity and good binding affinity for the human leukocyte antigen (HLA) classes as targets...
Antileishmanial activities of caffeic acid phenethyl ester loaded PLGA nanoparticles against Leishmania infantum promastigotes and amastigotes in vitro
Objective: To investigate and compare the antileishmanial effects of CAPE and (CAPE)PLGA NPs on Leishmania infantum (L. infantum) promastigotes and amastigotes in vitro. Methods: Efficacies of CAPE, (CAPE)PLGA NPs and fr...