Advances in vasculogenic mimicry in breast cancer
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 10
Abstract
Vasculogenic mimicry (VM) is a blood vessel-like structure formed by tumor cells and extracellular matrix, which can mimic the function of blood vessels while providing nutrients to tumors. Tumor angiogenesis plays an important role in tumor cell growth, invasion and metastasis. Anti-angiogenic drugs have been applied in breast cancer treatment, but the drug effects are still limited and susceptible to drug resistance. The formation of VM is one of the reasons leading to resistance to anti-angiogenic drugs. In addition, although the mechanism of VM formation has not been completely clarified, it is associated with a variety of poor prognostic factors in breast cancer, such as more aggressive staging, larger tumor diameter, and more prone to lymph node metastasis. Early intervention in the formation of VM may improve the prognosis of breast cancer, and therefore, targeting the VM may become a major new direction in the treatment of breast cancer. This article focuses on the molecular mechanisms of VM formation, the drivers of associated VM in breast cancer, the clinical relevance of VM in breast cancer, and the treatment targeting at VM.
Authors and Affiliations
TENG Yueyue, ZHOU Guiping， SHI Shiming， HUANG Shengchao， ZHANG Yuanqi
Keywords
Related Articles
- EP ID EP749045
- DOI -
- Views 62
- Downloads 0
The predictive value of uric acid/albumin ratio for no-reflow/slow-flow in patients after PCI for acute non-ST segment elevation myocardial infarction
Objective： To investigate the correlation between the uric acid/albumin ratio (UAR) and the occurrence of no-reflow/slow-flow after percutaneous coronary intervention (PCI) in patients with acute non-ST segment elevatio...
lncRNA ANCR regulating the effects of miR-497-5p on vascular lumen formation and apoptosis of gastric cancer cells
<b>Objective</b> To explore the effects of lncRNA ANCR regulating miR-497-5p on vascular lumen formation, apoptosis and PI3K/AKT signaling pathway of gastric cancer cells. <b>Methods</b> Gastric cancer cells were collect...
Epidemiological characteristics of notifiable infectious disease in Tongzhou District, Nantong from 2017 to 2022
Objective To analyze the epidemiological characteristics of notifiable infectious diseases in Tongzhou District of Nantong from 2017 to 2022, and provide scientific basis for developing targeted prevention and control st...
Analysis of risk factors for death in patients with sepsis
Objective To construct a death risk prediction model of sepsis, in order to provide reference for improving the early warning of death risk and improving the outcome of sepsis patients. Methods The data of 286 sepsis p...
Research progress on the index of consciousness 2 in pain management
Effective perioperative pain management is essential for accelerating recovery and minimizing adverse events, in which sensitive and reliable pain monitoring plays an indispensable role. The index of consciousness (IoC)...