Advances on the mechanisms of metformin in improving cognitive impairment in schizophrenia
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 5
Abstract
Schizophrenia is a common chronic mental disorder. Cognitive dysfunction is one of its core symptoms , which severely affects the social functioning of patients. Currently, antipsychotic medication treatments have poor efficacy in improving cognitive functions. Recent studies have found that metformin can improve cognitive dysfunction in patients with schizophrenia. However, the mechanism of action remains unclear. This review summarizes the therapeutic effects of metformin on cognitive dysfunction in schizophrenia patients such as improving insulin resistance, repairing neuronal damage, regulating neuroimmunity, and combating oxidative stress, thereby providing new insights for the treatment of cognitive dysfunction in schizophrenia.
Authors and Affiliations
Houming ZHU, Cuicui CUI, Weili XIA, Jiacui JI, Hongchang ZHANG, Xianbiao SU, Zhongbao WANG, Jiashu MA, Haoran CHU, Yunshao ZHENG, Ludong BAI, Ranran. LI
Research progress on the relationship between attention deficit and hyperactive disorder and inflammation
The pathogenesis of attention deficit and hyperactive disorder (ADHD) remains unclear. Evidence from epidemiological, biomarker, and genetic studies indicates that inflammation may play a crucial role in ADHD development...
Preliminary efficacy analysis of the flow diverter in the treatment of vertebral artery segment dissecting aneurysm
ObjectiveA preliminary study of the safety and efficacy of the Pipeline embolization device (PED) for the treatment of vertebral artery dissecting aneurysm (VADA).MethodsClinical data of 21 patients with VADA treated wit...
Advancements in the application of telemedicine for epilepsy patient management
Telemedicine, particularly during the COVID-19 pandemic, has rapidly evolved and been widely adopted worldwide, notably enhancing epilepsy patient management. Literature review reveals effective remote consultations and...
An intervention study of Orff-music therapy for long-term hospitalized patients with schizophrenia
[Objective] This research aims to investigate the impact of Orff music therapy on long-term schizophrenic patients in hospitals. [Methods] The study was a randomized, single-blind controlled trial conducted from April,20...
The rh-CSF1 improves mitochondrial function and cell apoptosis in neurons under oxygen-glucose deprivation
[Objective] To investigate the mechanism by which Colony Stimulating Factor-1 (CSF1) inhibits apoptosis in neurons subjected to oxygen-glucose deprivation (OGD). [Methods] Primary rat cortical neurons were divided into t...