ADVANTAGES OF MANUAL LIQUID-BASED CYTOLOGY IN CERVICOVAGINAL SMEARS WITH SPECIAL EMPHASIS ON CELL BLOCK
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 88
Abstract
BACKGROUND Cervical cancer is the second most common cancer among women worldwide and the leading cause of cancer deaths amongst women. Early detection is possible by cervical screening. Liquid-based cytology and Cell blocks prepared from residue can be useful adjuncts to smears for establishing a more definitive cytopathological diagnosis. MATERIALS AND METHODS This is a descriptive study. The present study was undertaken to prepare liquid-based smears and cell blocks from Liquid-based cytology specimens to aid in the diagnosis of Pap smears and to correlate with histopathology wherever possible. The study was undertaken in the period from July 2011 to July 2013. Total of 60 conventional Pap smears were obtained. Sample size was selected conveniently. In the present study, 60 cell blocks were prepared from MLBC specimen collected in a liquid fixative. Results were compared with cytology smears and histopathological correlation was obtained in 19 cases. RESULTS In the present study, out of 60 cases of cell blocks, 10 cases had no deposit. Of the other 50 cases, 7 cases (14%) were neoplastic and 43 (86%) were non-neoplastic. The sensitivity and specificity of cell block, LBC and CPS were 75% and 93%, 66% and 84%, 50% and 70% respectively for neoplastic lesions of cervix. Concordance Rate of CB/Histopathology vs. CPS/Histopathology is 74% vs. 54%. CONCLUSION In the present study, we found that cell blocks prepared from the LBC specimens aid in the diagnosis of neoplastic lesions of cervix and are particularly valuable in distinguishing carcinoma cervix from intraepithelial lesions. Cell blocks can be further subjected to ancillary tools like immunohistochemistry and HPV- DNA testing.
Authors and Affiliations
Shweta Kulkarni, Nandini Manoli, Nandish Manoli
Keywords
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- EP ID EP277884
- DOI 10.14260/jemds/2017/1326
- Views 86
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