Adverse Drug Reaction Monitoring in Chronic Obstructive Pulmonary Disease Patients in a Tertiary Care Centre
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Polypharmacy and comorbidities makes the patients with Chronic Obstructive Pulmonary Disease (COPD) highly susceptible to adverse drug reactions (ADRs). ADRs are associated with considerable morbidity, mortality, high direct and indirect medical costs. This study was undertaken to map out the ADR profile of COPD patients in the inpatient setting. The pattern, frequency, risk factors and causality of ADRs were assessed. The study was a cross sectional survey conducted among inpatients with COPD in a tertiary care hospital in Kerala. ADRs were monitored based on daily questioning for symptoms. Descriptive statistics was used for data analysis. 71% of the patients developed ADRs. Theophylline was the most frequently prescribed drug. Highest proportion of ADRs were due to Systemic Corticosteroids. Overall, the commonest ADR was dyspepsia, however Causality assessment showed that hyperglycemia due to systemic steroids was the most frequent ADR for which a causality could be suggested. Physicians should be especially vigilant about hyperglycemia associated with systemic use of steroids. Presence of comorbidities were not associated with increased prevalence of ADRs; but there was a higher prevalence among males which was statistically significant.
Authors and Affiliations
Sangeetha Purushothaman
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