Adverse Drug Reactions in Children Living with HIV/AIDS Receiving First Line ART
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Optimal adherence to anti-retroviral therapy can be improved by early detection, differentiation of selflimiting from potentially serious ADRs, and treatment of ADRs. The medical literature contains numerous studies in adults related to these complications; however, data in children is relatively sparse. The present study is designed to identify and document the common ADRs associated with ART in children. A total of 72 children receiving first line antiretroviral therapy at the Department of Pediatrics in a medical college, were included in the study. Adverse effects of the drugs and their effect on physical development of the patients were noted. Forty three patients (59%) had developed side effects with the start of first line ART regimen. Rashes (39.7%), lipodystrophy (26.4%), anemia (22) and abnormal liver function (8.3%) were the common side effects noted. Also noted were gastritis, altered lipid profile and hyperpigmentation. Nevaripine-induced rash and Stavudine-induced lipoatrophy are the most common ADRs in children. Close monitoring and regular follow up of these patients are important for early identification and treatment. This will help to substitute them with less toxic antiretroviral agents, if needed, and also to improve treatment adherence. It may also assistin preventing interactions with other drugs needed for various comorbidities in these children.
Authors and Affiliations
Dr Priya. P. R
Keywords
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