Adverse Drug Reactions in Children Living with HIV/AIDS Receiving First Line ART
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Optimal adherence to anti-retroviral therapy can be improved by early detection, differentiation of selflimiting from potentially serious ADRs, and treatment of ADRs. The medical literature contains numerous studies in adults related to these complications; however, data in children is relatively sparse. The present study is designed to identify and document the common ADRs associated with ART in children. A total of 72 children receiving first line antiretroviral therapy at the Department of Pediatrics in a medical college, were included in the study. Adverse effects of the drugs and their effect on physical development of the patients were noted. Forty three patients (59%) had developed side effects with the start of first line ART regimen. Rashes (39.7%), lipodystrophy (26.4%), anemia (22) and abnormal liver function (8.3%) were the common side effects noted. Also noted were gastritis, altered lipid profile and hyperpigmentation. Nevaripine-induced rash and Stavudine-induced lipoatrophy are the most common ADRs in children. Close monitoring and regular follow up of these patients are important for early identification and treatment. This will help to substitute them with less toxic antiretroviral agents, if needed, and also to improve treatment adherence. It may also assistin preventing interactions with other drugs needed for various comorbidities in these children.
Authors and Affiliations
Dr Priya. P. R
Keywords
Related Articles
- EP ID EP285224
- DOI -
- Views 65
- Downloads 0
Comparison of Clonidine and Dexmedetomidine as an Adjuvant to 0.375% of Ropivacaine in Supraclavicular Brachial Plexus Block: A Prospective Study
Background and Objective: Various adjuvants are added to local anesthetic to prolong the duration and faster the onset time of sensory and motor block and increase the quality of various types of peripheral nerve blocks...
Association of Serum Fetuin-A Concentration and Bone Mineral Density in Women with Postmenopausal Osteoporosis
Osteoporosis is a chronic, progressive, skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility. Biological pathways leading to os...
Diagnosis of Lymphocytic Thyroiditis Based on Grey Scale Evaluation in Correlation with Ultrasound Guided Fine Needle Aspiration Cytology
Aim: The aim of study was to validate the grey scale sonographic findings in lymphocytic thyroiditis using fine needle aspiration cytology which is taken as reference standard. Methodology: 89 patients with diffuse neck...
Changing Trends of HIV infection in Children Attending a Tertiary Care Hospital of Karnataka in Last Five Years
Children of today are the youth of tomorrow.HIV affects this very precious generation and bear grave consequences to our future, our nation, the continent and the world at large. Inspite of being largely preventable, pae...
Probiotics and antisecretory agents though costly are effective alone in mild to moderate non bacterial acute gastroenteritis
Objectives: To evaluate the utilization of Probiotics and Racecadotril for the patients of acute gastroenteritis (AGE) and subsequently their health outcome at an Infectious Disease Hospital and to observe the relationsh...