Adverse drug reactions in patients on aspirin therapy with concomitant antihypertensive medication in a tertiary care hospital of deccan plateau
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 2
Abstract
Introduction To know adverse drug reactions when Aspirin is prescribed with Antihypertensive medicationsMaterials and MethodsProspective observational study conducted in a tertiary care hospital total 60 patients of age Casuality assessment of all ADRs was done by Naranjo ADR scalegroup 18 to 65 years were included in the study It is a 12 week study clinical examination done at enrollment and with subsequent follow up at 48 and 12 weeksBase line investigations done at enrollment and at 12 weeks ADR monitoring done at each follow up ResultsOut of 45 patients who experienced adverse effects causality assessment shows that Aspirin is responsible for producing ADRs in 15 patients and in Betablocker therapy and 26 in Aspirin with thiazide diuretics and 16 in aspirin with ACE inhibitors or Calcium channel blockersremaining 30 patients Aspirin interaction is likely cause for ADRs Incidence of adverse effects is 40 in Aspirin with concomitant Conclusion This study shows Betablockers and Thiazide diuretics in treatment of hypertensionIncidence of ADRs is high in elderly patientsincreased incidence of Adverse drug reactions though these are mild ADRs when Aspirin is added to Betablockers and Thiazide diuretics in treatment of hypertensionIncidence of ADRs is high in elderly patientsKeywordsAspirin Betablockers Calcium channel blockers ACE inhibitors Thiazide diuretics Naranjo scale
Authors and Affiliations
Tamilisetti Vidya Sagar, Sanjay Kumar, Pramila Nayak
Keywords
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- EP ID EP478546
- DOI 10.18231/2393-9087.2018.0016
- Views 57
- Downloads 0
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