Adverse Drug Reactions of Nonsteroidal AntiInflammatorydrugs in Tertiary Care Hospital
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Background : In India use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is on a larger scale. It has been documented in several International and National studies that NSAIDs cause significant rise in the gastrointestinal adverse reactions. Aims and Objectives: The main aim of this study is to identify the incidence of the adverse drug reactions of the non-steroidal anti-inflammatory drugs and to assess the percentage & severity of the adverse reactions. Patients and Methods : A prospective Observational study was carried out in SVRR VT.Hospital,Tirupati.Total 200 patients of age between 18-60 years group fulfilling the inclusion criteria were enrolled for the study.This study will be carried out on patients who were prescribed Non-Steroidal Anti-Inflammatory Drugs for the past 1 year to observe the risks of adverse drug reactions.The severity of ADRs was categorized in to mild, moderate and severe using ADRseverity assessment scale of Hartwing and Siegle All ADRs their causative drug and therapeutic consequences were noted. outcome was assessed on all the follow-up days.The results will be analyzed using means, proportions, t-test (unpaired), ANOVA test and chi-square test. Results :.. The study found that females, elderly patients are some of the risk factors. Maximum ADRs are mild to moderate in nature and no serious or severe reaction developed after prescribing NSAIDs which is the positive point. Conclusion: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are widely prescribed drugs. Monitoring of adverse drug reaction is an important tool to prevent the damage to a system like gastrointestinal, cardiovascular and derangement of kidney and liver functions.Fixed dose combinations of NSAIDs are used less which goes in favour of rational prescribing practice.Forty to sixty years of age , female sex are the main risk factors for causing ADRsIn more than fifty percent of the patients, gastro protective agents have been used and rest of the patients in whom gastro protective agents are not used, they have suffered from the gastrointestinal symptoms. It suggests that guidelines for prescribing NSAIDs are necessary to follow.Maximum ADRs are mild to moderate in nature and no serious or severe reaction developed after prescribing NSAIDs which is the positive point.
Authors and Affiliations
Dr. V. Naga Jyothi, Dr. Swathi Rapole, Dr. Praveena Gungam, Dr. K. Akshara
Keywords
Related Articles
- EP ID EP239196
- DOI 10.9790/0853-1610021424
- Views 101
- Downloads 0
Postoperative Spinal Wound Infection in Neurosurgical wards at RIMS, a Single Centre Experience
With modern surgical techniques and perioperative antibiotics, spinal infection after surgery is relatively uncommon. Certain patient and surgical treatments are however at higher risk and should be treated with extra ca...
A Study on Reproductive Tract Infections among Women of Reproductive Age Group in Slums of Burdwan Municipal Area, West Bengal
Aim of this study is to determine the prevalence of reproductive tract infections among women of reproductive age group in slums of Burdwan Municipal area by syndromic approach. Materials and method: All women of reprodu...
Comparison of the Antimicrobial Efficiency of Chlorhexidine And Cacao Bean Husk Extract Mouth Rinsesin Children
Aim : The aim of this study is to compare the antimicrobial efficiency of chlorhexidine and cacao bean husk extract mouth rinses in children. Material And Methods: This study comprise of 210 children aged 10-14 year old...
Langerhans Cell Histiocytosis: A Case Report and Review
Langerhans’cellhistiocytosis (LCH) (Histiocytosis X) is a rare disease of unknown cause characterized by oligoclonal proliferation of Langerhans cells. It occurs mostly in children and young adults and involves one or mo...
A Case of Left Atrial Myxoma – A 2 Dimensional Echocardiography Diagnosis:
Myxoma (benign tumor) is the most common tumor of the heart. Myxoma can occur in any chamber of the heart but most commonly arises in the left atrium. It is diagnosed using 2 Dimensional transthoracic echocardiography (2...