Aerobic Exercise Improves Brain Natriuretic Peptide and C-Reactive Protein Among Men and Women With Coronary Artery Disease
Journal Title: International Journal of Applied Exercise Physiology - Year 2018, Vol 7, Issue 4
Abstract
Background: Coronary artery disease (CAD) is considered as an important cause of mortality. We investigated the effect of 8 weeks aerobic exercise training (AET) on two key markers: brain natriuretic peptide (BNP) as a cardiac hypertrophy indicator and C- reactive protein (CRP) as an inflammatory marker among men and women with coronary artery disease. Methods: In a randomized two-arm parallel single-blind trial, sixty patients with CAD participated and divided into four groups: women aerobic exercise (WAE), men aerobic exercise (MAE), women control (WC), and men control (MC). The WAE and MAE performed exercise protocol on a pre-calibrated cycle ergometer (3 sessions per week, for 8 weeks). The experimental groups exercised for 15 minutes with 55-60 percent of their target heart rates (220- age) in the first week of the intervention, followed by adding 5 minutes per week to the exercise duration. Serum BNP and CRP were measured at the baseline and during the following 8 weeks exercise intervention. We aimed to investigate whether exercise downregulates CAD biomarkers and improves the cardiac performance in CAD patients. Additionally, we tried to provide a suitable training program at the level of physical fitness of the patients, which would reduce the death rate from cardiovascular disease of the middle-aged citizens in the country and increase the life years without disability in cardiovascular and healthy patients, as well. Results: The BNP and CRP levels were significantly higher in women compared to men both before and after exercise. They significantly decreased at Post-Ex compared to Pre-Ex in MAE and WAE. Further, CRP was significantly higher in women in comparison with men at Pre-Ex and Post-Ex. Additionally, BNP was significantly lower in women compared to men at Pre-Ex and Post-Ex. Conclusion: These findings suggest AET as an effective exercise regime for ameliorating these markers in patients with coronary artery disease.
Authors and Affiliations
Najmeh Sheikhian, Mohammad Ali Ostovan, Farhad Daryanoosh, Farnaz Sharifi
Keywords
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- EP ID EP571987
- DOI 10.30472/ijaep.v7i4.309
- Views 47
- Downloads 0
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