Age related changes of the central lamina cribrosa thickness, depth and prelaminar tissue in healthy Chinese subjects
Journal Title: International Journal of Ophthalmology - Year 2018, Vol 11, Issue 11
Abstract
"AIM: To investigate the variation in the central lamina cribrosa thickness (cLCT), and the central anterior lamina cribrosa surface depth (cALCSD), as well as the central prelaminar tissue thickness (cPLTT) related to age in healthy Chinese subjects. METHODS: A total of 96 eyes from 96 Chinese healthy subjects were recruited. According to age, the 96 cases were divided into three groups: the young group (YG, 18-39y), middle-age group (MG, 40-59y) and older-age group (OG, 60y and above). Lamina cribrosa images were obtained from all participants using radial linear protocol by enhanced depth imaging spectral-domain optical coherence tomography. The cLCT, cALCSD and cPLTT were calculated from the average value of the lamina cribrosa thickness, anterior lamina cribrosa surface depth and prelaminar tissue thickness in the optic nerve head (ONH) centre point and paracentral points (150 μm from the centre point in the horizontal and vertical directions). RESULTS: For the total subjects, the mean cLCT, cALCSD and cPLTT were 235.18±41.27, 358.02±93.80 and 182.02±92.11 μm, respectively. No statistically significant differences in cLCT, cALCSD or cPLTT were found between gender and different eyes (P=0.27-0.92). The cLCT of the OG was the thickest among the three groups, while the cPLTT of the YG was the thickest among the three groups (P<0.05). Age was positively correlated with cLCT (r=0.42, P<0.001), and negatively correlated with cPLTT (r=-0.24, P=0.02). No significant correlation was found between the age and cALCSD (r=-0.06, P=0.55). And no correlation has been found between axial length and cLCT, cALCSD and cPLTT (P=0.11-0.81). CONCLUSION: The impact of age on the cLCT and the cPLLTT should be taken into account when analysing glaucoma and other diseases related to lamina cribrosa."
Authors and Affiliations
Xing Liu
Keywords
Related Articles
- EP ID EP477303
- DOI 10.18240/ijo.2018.11.17
- Views 62
- Downloads 0
A new interpretation and quantitative method for diplopia test: 304 cases of ocular motor nerve palsy for clinical test and verify
We introduce a new interpretation and quantitative method for computerized diplopia test. By comparing this new method to the Hess screen test, we validate its applicability among 304 patients with ocular motor nerve pal...
Long-term follow-up of vitrectomy in patients with pathologic myopic foveoschisis
"AIM: To report the long-term surgical outcomes of pathologic myopic foveoschisis (MF) following vitrectomy. METHODS: We performed a retrospective case series analysis of 50 consecutive patients diagnosed with MF who exp...
Vasoactive intestinal peptide, a promising agent for myopia?
"AIM: To investigate the role of vasoactive intestinal peptide (VIP) in form-deprivation myopia (FDM). METHODS: FDM was created in three groups of eight chicks by placing a translucent diffuser on their right eyes. Intra...
Adenocarcinoma of the nonpigmented ciliary epithelium manifested as an anterior chamber mass
Letter
Prevalence of amblyopia in congenital blepharoptosis: a systematic review and Meta-analysis
"AIM: To conduct a systematic review and Meta-analysis of the published literature to evaluate the pooled prevalence rate of amblyopia in patients with congenital ptosis. METHODS: We searched the PubMed, Embase, the Coch...