Ageing: The Emerging Area of Bio-gerontology- A Review
Journal Title: Journal of Clinical Medical Research - Year 2022, Vol 3, Issue 1
Abstract
Ageing is linked to a progressive loss of physical function and fitness, imperfect maintenance and repair systems. Many theories, such as evolutionary (mutations), telomere shortening, linked to a system (neuroendocrinologic, immunologic) appear to be the molecular and cellular hallmarks of ageing. The ultimate causes of ageing remain not yet elucidated, but they seem to be multifactorial. However, the consequences of ageing are better identified and leading to adapted gerodontologic therapies. Geroscience involves mostly all oral pathologies, focusing on endocrine and infectious disorders of periodontal diseases, involving the dental pulp and carious lesions, syndromes (e.g. trisomy 21 syndrome), salivary dysfunctions, burning mouth syndrome and tumor pathogenesis. With the increasing number of patients over 80+, gerodontology pave the way for a domain oriented toward therapeutic dentistry, leading to an extended lifespan. The future of ageing therapies involves selective elimination of senescent cells (SNSs), also known as senolysis, which prevents various age-related diseases. Most pathologies are implicated on the effects of ageing without exerting undesirable side effects.
Authors and Affiliations
Michel Goldberg1*
Alteration of Endocrine Functions and Reproductive Outcome Following Consumption of Edible Crops Grown Around E-Waste Dumpsite Using Albino Wistar Rat Model
Electronic waste (e-waste) is the term used to describe old, end-of-life or discarded appliances using electricity in one form or the other which are destined for reuse, resale, salvage, recycling but most importantly di...
The Strange Case of Galte or Beyond the Realm of What is Physical
Creativity is like a willing mistress. It makes you feel full and content but at times, it does not. Sometimes it hides; and indeed, you miss it. At times, I have suffered the dilemma of the blank page. What do I write?...
Statistical Ethics in Medical Research: A Narrative Review
Bioethics necessitates the meticulous planning, application and interpretation of statistics in medical research. However, the pervasive misapplication and misinterpretation of statistical methods pose significant challe...
A Case of Pregnant Woman with Severe Mitral Regurgitation Demonstrating Left Ventricular Non-compaction
Left ventricular non-compaction is a rare form of cardiomyopathy. It is characterized by a thin compacted epicardial layer and a noncompacted endocardial layer with significant wall trabeculations and intertrabecular rec...
Psychiatric Evaluation of the Effects of COVID-19
The current COVID-19 pandemic has hit the entire world population hard and it is assumed that its consequences on mental health will be as important as its current physical repercussions. However, the evidence on this...