AKTIVITAS HIPOLIPIDEMIK EKSTRAK ETANOL HERBA KROKOT (Portulaca oleracea L.) PADA TIKUS OBESITAS DENGAN PARAMETER TRIGLISERIDA
Journal Title: As-Syifaa Jurnal Farmasi - Year 2018, Vol 10, Issue 1
Abstract
Hypolipidemics a drug used to lower plasma lipid levels in the blood. This study aimed to examine the hypolipidemic activity of ethanol extract of purslane herb (Portulaca oleracea L.) against the triglyceride level reduction in obese mice. The purslane herb contains omega-3, flavonoids and hight ascorbic acid as a lowering of triglyceride levels in the blood. This study used 15 malerats divided into 5 groups. Group I (negative control) was given Na.CMC 1%, group II (positive control) was given Gemfibrozil, group III, IV, and V were given ethanol extract of purslane herb with dose of 100 mg/kgBW, 200mg/kgBW, and 300 mg/kgBW as therapy group. All the administration were done orally once a day for 16 days. The measurement of triglyceride level was performed on early triglycerides before induction, after induction and after therapy. Before therapy, the rats were given hight-calorie diet. The results showed that the ethanol extract of purslanes herb has activity as hypolipidemic in lowering trygliseride level in obese mice. From the statistic result of One-Way ANOVA followed by LSD test, it can be concluded that the ethanol extract of purslane herb of the dose 100 mg/kgBW provide the most effective hypolipidemic activity that triglyceride level is not significantly different from positive control group (p>0,05).
Authors and Affiliations
Rizqi Nur Azizah, Bayu Putra, Rafika Tobis
Keywords
Related Articles
- EP ID EP540000
- DOI -
- Views 63
- Downloads 0
EFEK PEMBERIAN MINYAK ZAITUN (Olive oil) TERHADAP PERUBAHAN PROFIL LIPID PADA TIKUS PUTIH (Rattus novergicus)
This research aims to know the effects of olive oil to changes profil lipid (total cholesterol, LDL, HDL, and triglycerides) in the blood of the Rattus novergicus who were given a high cholesterol diet. This research...
UJI AKTIVITAS ANTIOKSIDAN BUAH SEMANGKA (Citrullus lanatus) DENGAN METODE FRAP
Have been conducted a research about antioxidant activity assay at watermelon (Citrullus lanatus) using FRAP method. Watermelon is known contains vitamin A, B, C, and lycopene. The aim of research were to determine the a...
ANALISIS AKTIVITAS ANTIOKSIDAN SEDIAAN PROPOLIS YANG BEREDAR DI KOTA MAKASSAR DENGAN METODE FRAP (Ferric Reducing Antioxidant Power)
Antioxidants are chemical compounds that can donate one or more electrons to free radical, so that free radicals that can be suppressed.This study aimed to obtain and provide scientific evidence to the public regarding t...
FORMULASI SEDIAAN SABUN PADAT DARI MINYAK NILAM (Pogostemon cablin Benth)
Solid soap is a soap made from fat saponification reaction of solid sodium hydroxide, which is used to cleanse the body. Patchouli essential oil content of patchouli alcohol discount antibacterial and anti-inflammatory....
STUDI PENGGUNAAN OBAT DIARE PADA ANAK PASIEN RAWAT INAP DI RSUD ANDI DJEMMA MASAMBA KABUPATEN LUWU UTARA PERIODE JANUARI-DESEMBER 2014
Diarrhea is generally caused by the bacteria contamined in food and drink. If the bacteria are not the right treatment, it can be fatal and cause death. This research aimed to present the drug use on the diarrhea patient...