Aldose Reductase Inhibitors for Diabetic Cataract: A Study of Disclosure Patterns in Patents and Peer Review Papers
Journal Title: Ophthalmology Research: An International Journal - Year 2014, Vol 2, Issue 3
Abstract
Aims: To investigate, for 13 aldose reductase inhibitors that had been in development for diabetic cataract, whether patent documents could provide earlier dissemination of knowledge to the ophthalmology community than peer review papers. Methodology: Searches for intellectual property disclosures were conducted in our internal database of ophthalmology patent documents, and were supplemented by online searches in the public Espacenet and Google Patents databases. Searches for peer review papers were performed in Pub Med and Google Scholar, and in our internal database of machine-readable ophthalmology publications. Results: For sorbinil, tolrestat, fidarestat and GP-1447 patent documents clearly preempted the peer review literature in terms of data-supported information on potential effectiveness in diabetic cataract, typically by 7-17 months. For alrestatin, zenarestat, zopolrestat, indomethacin, and quercitrin academic journals were clearly first to properly report this therapeutic utility, preempting the corresponding patents by 6 months to several years. For ponalrestat, risarestat, epalrestat, and lidorestat claims of utility in diabetic cataract were first made in patent documents, but with insufficient or incomplete support. Conclusion: Our results suggest that including patent documents in the routine monitoring of newly disclosed knowledge could significantly improve the comprehensiveness of the literature base in ocular pharmacology, and has the potential to alert researchers to emerging drug candidates earlier than reports in the peer review literature.
Authors and Affiliations
H. A. M. Mucke, E. Mucke, P. M. Mucke
Keywords
Related Articles
- EP ID EP338952
- DOI 10.9734/OR/2014/7224
- Views 106
- Downloads 0
Ishihara Electronic Color Blindness Test: An Evaluation Study
Purpose: Evaluation of computer based color deficiency test. Materials and Methods: Two hundred and sixty seven volunteers have been checked using both traditional Ishihara plates and a computer diagnosis program using L...
Association of the CASQ1 Gene SNP rs3838216 with Graves’ Ophthalmopathy and Hashimoto’s Thyroiditis in Patients with Thyroid Autoimmunity
The pathogenesis of Graves’ ophthalmopathy is poorly understood, but there is evidence for the involvement of calsequestrin (CASQ1) as an autoantigen. Aim: To compare the frequency of the single nucleotide polymorphism...
Relationship between Petrochemical Pollution and Oculo-Visual Health in Onelga Region of the Niger Delta
Common sense and simple economics suggest that countries endowed with an abundance of natural resources should prosper. Yet over many years, it has been observed that developing nations rich in oil, gas or mineral resour...
Genetic Predisposition to Advanced Retinopathy of Prematurity (ROP) Gains Support
Aims: The purpose of this short review is to summarize the recent developments in the genetics of retinopathy of prematurity. Background: Retinopathy of prematurity is a well known blinding disorder in children in both d...
Barriers to the Second Eye Cataract Surgery Amongst the Rural Population of Western Maharashtra, India
Aim: To identify the barriers which prevent the uptake for the second eye cataract surgery (SECS), amongst the rural population. Study Design: A hospital based observational study. Place and Duration of Study: Department...