ALK-1 Positive Anaplastic Large Cell Lymphoma Presenting as Extensive and Exclusive Osseous Involvement: Report of a Rare Association and Review of Literature
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 1
Abstract
Abstract Primary Bone Lymphomas (PBLs) are uncommon. Most of these tumours are Non Hodgkin Lymphoma (NHL) with Diffuse Large B-cell Lymphoma (DLBCL) being the most common. Anaplastic Large Cell Lymphoma (ALCL) constitutes approximately 2% of all NHL and involves both nodal and extra nodal sites. ALCL presenting as exclusive and extensive bone involvement is rare. We report a case of 31-year-old man who presented with osseous involvement only. Imaging showed multiple lytic lesions involving the vertebral column, ribs and sternum. Clinical differential diagnosis included osteomyelitis and bone neoplasms. Histopathology and immunohistochemistry of the lytic lesion proved it to be Anaplastic Lymphoma Kinase (ALK-1) positive ALCL. The patient relapsed three months after completion of six cycles of combination chemotherapy with Cyclophosphamide, Hydroxydaunorubicin, Vincristine and Prednisone (CHOP).
Authors and Affiliations
Swetha Lakshmi Narla, Ann Joseph Kurian, Annapurneswari Subramanyan, Ashok Parameswaran
Keywords
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- EP ID EP506234
- DOI 10.7860/JCDR/2018/31109.11040
- Views 39
- Downloads 0
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