ALKALINE PHOSPHATASE (ALP) ELEVATION IS A BIOMARKER FOR CHOLESTASIS, EPSTEIN-BARR VIRUS (EBV) AND OSTEOSARCOMA (REVIEW)
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 5
Abstract
Alkaline phosphatase is a “metalloenzyme” which at alkaline pH catalyze the hydrolysis of “organic phosphate ester”. Different studies were done to find the function of SALP in Osteosarcoma patients. On analysis it was seen that increased SALP levels are linked with existence of metastasis. The elevated level of SALP is particularly linked with deprived rate of “overall survival” or “event free survival” (OS & EFS). SALP levels hence act as a useful, efficient and suitable biomarker for osteosarcoma. Decreased level of Dickkopf-1 by bortezomib; cause stimulation of osteoblasts, which then cause increase in formation of bone. Increased level of “bone specific alkaline phosphatase” (bALP) and “osteocalcin” specifies the increased bone formation. Elevation of ALP, bilirubin and GGT act as the indicator or marker for cholestasis according “primary lab evaluations”. ALP levels can also rise in late pregnancy because of a “different form of enzyme” produced by placenta but GGT levels are normal here. Common type of “primary EBV hepatitis” is that in which “biochemical abnormalities” of increased ALP are predominant. In almost 75% cases ALP levels are so high that they can be easily detected and calculated. It can be then concluded that ALP when rise from its normal level can act as an indicator for EBV, cholestasis and osteosarcoma.
Authors and Affiliations
Dr. Sikander Ali
Keywords
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