Allablanckia floribunda hypotensive activity on ethanol induced hypertension in rats
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 2
Abstract
Background: Chronic alcohol intake is related to hypertension. In the present work, we investigated the effect of Allablanckia floribunda Oliver (Clusiaceae) aqueous extract in alcohol-induced hypertensive rats and on related oxidative stress damages. Methods: Alcohol-induced hypertensive rats (AHR) was obtained by oral administration of ethanol (3 g/kg/day during 8 weeks). Blood pressure and heart rate were evaluated using the direct cannulation method. The effects of the extract on lipid profile as well as kidney and liver functions were studied. Free radical scavenging and antioxidant properties of the extract were evaluated by colorimetric method. The effects of A. floribunda were evaluated after 4 weeks of treatment with alcohol. Results: At the doses of 200 and 400 mg/kg/day, A. floribunda significantly decreased the mean blood pressure of AHR by 14.06 and 23.25 % respectively. Administration of the plant extract lead to the reduction of total cholesterol by 41.50% and 43.06%, HDL-cholesterol by 22.16 and 30.15% and artherogenic index by 69.78 and 74.43%, respectively at the doses of 200 and 400 mg/kg, as compared to untreated hypertensive rats. A. floribunda (200 and 400 mg/kg) decrease bilirubine (12.98 and 16.88%), urea (23.32% and 32.26 %), ALT (10.73 and 27.97%) and AST (29.80 and 42.22%) of treated AHR, respectively. The plant extract also reduced superoxide dismutase (SOD), malondialdehyde (MDA) and catalase and increased the reduced glutathione (GSH) concentration in aorta, heart, kidney and liver of AHR. Conclusion: These results suggest that the aqueous extract of A. floribunda possesses antioxidant and hypotensive activity in alcohol-induced hypertension.
Authors and Affiliations
Danielle Claude Bilanda, Paul Désiré Djomeni Dzeufiet, Orelien Mtopi Bopda, Pierre Kamtchouing, Théophile Dimo
Keywords
Related Articles
- EP ID EP49795
- DOI -
- Views 154
- Downloads 0
Pharmacological evaluation of Sedative and Hypnotic activities of methanolic extract of Lycopus europaeus in mice
The methanolic extract of Lycopus europaeus was evaluated on central nervous system. The methanolic extract produced significant sedative effect at the doses of 200, 400 and 600 mg/kg (by oral route), compared to refer...
Brilliant future of phytomedicines in the light of latest technological developments
The phytomedicine have been used throughout the world as an integral part of our health care system since long time ago. The knowledge of traditional therapies, inherited from ancestors, is highly deep-rooted and time...
Assessment of antioxidant activity of Ficus asperifolia Miq aqueous extract - In vitro studies
Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to human against degenerative diseases. The aim of this study was to assess the in vitro antioxidant activity of...
Comparative root anatomy and thin layer chromatographic identification of Boerhavia diffusa L. and Boerhavia erecta L.
“Punarnava” is an important rejuvenative drug, widely used in the indigenous system of medicine. The root is the officinal part and used in various formulations in Ayurveda and found two varieties in the commercial mar...
Effect of aqueous extract of Talinum triangulae (water leave) in lead- induced chromosomal aberration
Phytomedicine is a subject that is now gaining relevance worldwide aiding treatment for diseases that were once incurable among folks in which genotoxicity is a prominent one. The present study was designed to examine...