Allablanckia floribunda hypotensive activity on ethanol induced hypertension in rats
Journal Title: UNKNOWN - Year 2018, Vol 7, Issue 2
Abstract
Background: Chronic alcohol intake is related to hypertension. In the present work, we investigated the effect of Allablanckia floribunda Oliver (Clusiaceae) aqueous extract in alcohol-induced hypertensive rats and on related oxidative stress damages. Methods: Alcohol-induced hypertensive rats (AHR) was obtained by oral administration of ethanol (3 g/kg/day during 8 weeks). Blood pressure and heart rate were evaluated using the direct cannulation method. The effects of the extract on lipid profile as well as kidney and liver functions were studied. Free radical scavenging and antioxidant properties of the extract were evaluated by colorimetric method. The effects of A. floribunda were evaluated after 4 weeks of treatment with alcohol. Results: At the doses of 200 and 400 mg/kg/day, A. floribunda significantly decreased the mean blood pressure of AHR by 14.06 and 23.25 % respectively. Administration of the plant extract lead to the reduction of total cholesterol by 41.50% and 43.06%, HDL-cholesterol by 22.16 and 30.15% and artherogenic index by 69.78 and 74.43%, respectively at the doses of 200 and 400 mg/kg, as compared to untreated hypertensive rats. A. floribunda (200 and 400 mg/kg) decrease bilirubine (12.98 and 16.88%), urea (23.32% and 32.26 %), ALT (10.73 and 27.97%) and AST (29.80 and 42.22%) of treated AHR, respectively. The plant extract also reduced superoxide dismutase (SOD), malondialdehyde (MDA) and catalase and increased the reduced glutathione (GSH) concentration in aorta, heart, kidney and liver of AHR. Conclusion: These results suggest that the aqueous extract of A. floribunda possesses antioxidant and hypotensive activity in alcohol-induced hypertension
Authors and Affiliations
Danielle Claude Bilanda, Paul Désiré Djomeni Dzeufiet, Orelien Mtopi Bopda, Pierre Kamtchouing, Théophile Dimo
Keywords
Related Articles
- EP ID EP588724
- DOI -
- Views 56
- Downloads 0
GC-MS, phytochemical analysis and in vitro antioxidant activities of leaves of Canavalia cathartica Thouars
Plants have been used for thousands of years to flavour and conserve food, to treat health disorders and to prevent diseases including epidemics. The knowledge of the anti-oxidant properties has been a promising method o...
In vitro immunitary impact and antioxidant activity of aqueous extracts of Maprounea africana Müll (Euphorbiaceae) and Mitragyna stipulosa O.Kze (Rubiaceae)
This study aims to investigate the in vitro immunitary impacts and antioxidant activity of aqueous extracts of Maprounea africana (Euphorbiaceae) leaves and Mitragyna stipulosa (Rubiaceae) stem barks. Impact on leukocyte...
Pharmacological and phytochemical studies on Acacia modesta Wall; A review
The use of plants with therapeutic properties is as ancient as human civilization. Acacia modesta belongs to family Fabaceae and is a deciduous tree which has medium or small size. Traditionally, it has been used to trea...
The Effects of Probiotics Supplementation on Milk Yield and Composition of Lactating Dairy Cows
The effects of microbials dietary supplements on performances and health of the animals, in recent is becoming very critical. Consequently, direct-feds microbials (DFM), is an area of interest of several authors, since l...
Pharmacognosy and Phytochemical Evaluation of Hygrophila auriculata (Schumach.) Heine. Root
The genus Hygrophila auriculata (Schumach.) Heine belongs to family Acanthaceae found in India. Commonly known Kokilaksa, as in Sanskrit. Root and seeds used as tonic, for asthama and dysentery (Bhuktar, 2000). Decoction...