Allele Frequencies of HLA-A, B and DRB1 among People of Fars Ethnicity Living in Tehran
Journal Title: Iranian Journal of Blood and Cancer - Year 2011, Vol 3, Issue 4
Abstract
Background: Human leukocyte antigens (HLA) are polymorphic cell surface proteins. Distribution of HLA alleles vary among different racial and ethnic populations in unrelated stem cell registries. Determination of HLA allele frequencies in different ethnic groups is useful for population genetic analyses. Materials and Methods: Based on data available from the Iranian Stem Cell Donor Registry, HLA-A, B, DRB1 allele frequencies were evaluated from 244 individuals who were recruited as unrelated volunteer donors by PCR-SSP method in people of Fars ethnicity living in Tehran, Iran. Results: The most frequent alleles found were HLA-A*02(19.8%), HLA-A*03(13%), HLA-A*11 and -24 (12.5%), HLA-B*35(17.7%) HLA-B*51(13.2%), HLA-DRB1*11(20.8%), whereas HLA-A*34 and HLA-A*44 (0.2%), HLA-B*47, B*54, B*56, B*73(0.2%), and HLA-DRB1*09 (0.4%) were the least frequent alleles. Conclusion: Identifying HLA allele frequencies in different ethnic groups, helps in designing a better plan for development of donor centers in different provinces of a country, and a more precise prediction of donor size in the registry, in addition to finding suitable donors for patients in need of hematopoietic stem cell transplantation.
Authors and Affiliations
Mojgan Shaiegan, F. Yari, H. Abolghasemi, N. Bagheri, M. Paridar, A. Heidari, Sh. Kashani, S. Riazi
A Case of Gaucher's Disease with Recurrent Fetal Loss and Antiphospholipid Antibody Syndrome
This article has no abstract.
Pediatric Meduloblastoma and the Prognostic Value of MIB-1 Proliferative Factor
Background: Medulloblastoma is the most common malignant brain tumor in children. The important factors in predicting survival are the extent of disease, proliferation index of the tumor cells, histopathologic class and...
Congenital Leukemia: A Case Report
This article has no abstract.
The Survey of Effective Agents on Factor VIII and IX Inhibitors in Patients with Hemophilia A and B in Kermanshah Province
Background: Hemophilia is the most frequent severe hereditary hemorrhagic disease due to deficiency of coagulation factors VIII (Hemophilia A) or IX (Hemophilia B) in plasma. We aimed to identify patients with hemophili...
Preparation of Plasminogen by Affinity Chromatography
Background: Plasminogen is one of the compounds derived from human plasma. Activation of plasminogen produces plasmin. Plasmin is able to lyse fibrinogen, fibrin, and some other human plasma proteins. The aim of the pres...