Allelic Diversity of Vaccine Candidate Antigen, PfMSP6 (Merosoite Surface Protein 6) of Malaria Plasmodium Falciparumin South-East of Iran
Journal Title: PARIPEX-Indian Journal of Research - Year 2015, Vol 4, Issue 9
Abstract
Plasmodium falciparummerozoite Surface Protein-6 (PfMSP6) is a potential vaccine candidate at an early stage in development. Different subtypes of Plasmodium falciparum including 3D7 and K1 had different diversity and then each had a potentially capable for vaccine generation. Thus this study assessed prevalence of 3D7 and K1 in southeast of Iran. This study was conducted on 65 infected patients with Plasmodium falciparum in different parts of Sistan and Baluchistan, southeast of Iran. Blood was collected from each individuals and genomic DNA was extracted. Initially DNA was amplified by external primers and then obtained products were amplified using nested PCR to determined prevalence of K1 and 3D7 in this part of Iran. Eventually obtained data was analyzed by SPSS software. The mean age of affected individuals was 39 years and 51.5 percent of them were male and 48.5 percent was female.. Our study revealed that 3D7 (52.4%) frequency was higher than K1 (37.7%). 9.9% of patients had the mix infection of 3D7 and K1. Most patients infected by both alleles of 3D7 and K1were residues of Chahbahar city. respectively.3D7 subtype of Plasmodium falciparum was common in southeast of Iran and based on low diversity of use of vaccination in this part of Iran in successful.
Authors and Affiliations
Adel Ebrahimzadeh, Taregh Bamedi, Khadijeh Saryazdi
Keywords
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