Alloimmunization in Sudanese Leukemic Patients with Multiple Blood Transfusions
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Background: Blood transfusion is one of effective treatments which used to decrease morbidity and mortality rate in leukemia patients, but it can results in development of alloimmunization to red blood cell antigens, which often results in difficulties in finding compatible blood and a higher risk of delayed hemolytic transfusion reactions. Objective: The current study aimed to determine the frequency of allo antibodies among Sudanese multiply blood transfused leukemic patients in Khartoum state, the study also aimed to correlate between the frequency of alloimmunization and duration of blood transfusion therapy. Materials and Methods: This study was conducted in Khartoum state between August 2015 and January 2016. 176 multiply transfused leukemic patients were included in this study . previous blood transfusion and clinical data of all the patients were obtained including age of patients, duration of transfusion and other health problems, Blood samples were collected from each participant, Then ABO, RhD grouping was checked, Alloantibody screening and identification was done for each patients. Results: we found that 13 patients (7.3%) had RBC alloantibodies. Anti-K was detected in four patients (2.2%), while anti-c in one (0.56% anti-E was detected in three patients (1.7%), anti C in one patient (0.56% ) and anti Fya in two patient (1.13%). O blood group was found to be the most frequent (38.5%) among the alloimmunized patients, whereas blood group AB was least frequency (7.7%). The prevalence of blood group A and B were 30.7% and 23.1% respectively Pearson’s correlation has shown significant positive correlation between alloimmunization and duration of blood transfusion therapy (r = 0.343, P-value 0.001). Conclusions: we observed that 7.3% of study population were alloimmunized against RBCs antigens. The majority of detected antibodies were against Kell and Rh blood group systems and the Incidence of alloimmunization increases with duration of transfusion therapy. Multiply transfused leukemic patients should be screened regularly before blood transfusion against red cell alloantibodies to reduce the rate of RBC alloimmunization and hemolytic transfusion reactions.
Authors and Affiliations
Safa Salah Ahmed Abed Elrahman, Leena Babiker Mirghani
Keywords
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- EP ID EP238252
- DOI 10.9790/0853-1611036165
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