ALOE VERA GEL REVERSES HAEMOSTATIC DERANGEMENT IN RATS FOLLOWING SALT LOADING.
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 2
Abstract
This research investigated the effect of Aloe vera (gel) on haemostatic status of high salt loaded rats. Twenty wistar rats (200-250g) were randomly assigned into 4 groups (n=5) thus: control, Aloe (600mg/kg of Aloe vera), Salt-fed [SF] (high salt diet- 8% NaCl in feed and 1% NaCl in H2O) and salt treated [SF+Aloe] (high salt diet+600mg/kg of Aloe vera) groups. All groups took rat feed and water throughout the duration (six weeks) of treatment. Blood samples were collected via cardiac puncture and tail pricking for analysis. Platelet count was significantly decreased in Aloe (p<0.001) and SF (p<0.01) groups compared with control. But it was significantly (p<0.001) increased in SF+Aloe group compared with other groups. MPV and P-LCR were significantly increased in SF+Aloe group compared with Aloe (p<0.05) and SF (p<0.01) groups. Clotting, bleeding and prothrombin times were significantly (p<0.01) increased in SF group compared with control and Aloe groups. They were however significantly (p<0.01) decreased in SF+Aloe group compared with SF group. High salt intake caused deleterious haemostatic effects by reducing platelet count and increasing clotting, bleeding and prothrombin times but Aloe vera however ameliorated these effects and can therefore be effective in treating bleeding disorders.
Authors and Affiliations
Augustine Lishilinimye Udefa
Keywords
Related Articles
- EP ID EP620006
- DOI -
- Views 122
- Downloads 0
PROGRAMMABLE BIO NANO CHIP SYSTEM - A REVIEW
Is there a revolution afoot in diagnostic medicine? Could a credit cardsized, disposable cartridge and a toaster-sized analyser use artificial intelligence (AI) to digitize biology—detecting and diagnosing sickness insta...
A REVIEW ON CAUSES, STAGES AND TREATMENTS USED IN ALZHEIMER'S DISEASE
Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disorder which reduced the person’s ability to think clearly, perform everyday tasks and ultimately, remember who they even are. As it worsens over the...
A VARIANT OF ANDROGRAPHIS OVATA C.B. CLARKE (ACANTHACEAE) - AN ENDEMIC MEDICINAL PLANT FROM INDIA
The aim of the present research was to investigate the identification of a variant ternate phyllotaxy of Andrographis ovata. This is the first announce on variant ternate phyllotaxy of Andrographis ovata Clarke.
AWARENESS TO HAZARDS OF SUN EXPOSURE AND USE OF SUNSCREEN AMONG GENERAL POPULATION IN MADINAH CITY, SAUDI ARABIA, 2017-2018: CROSS-SECTIONAL STUDY.
Background: There is a consensus in the published literature upon the association between intense exposure to ultra-violate (UV) radiation and increased risk of skin cancer. The present study aims to investigate the awar...
A COMPARATIVE STUDY BETWEEN TRAMADOL AND FENTANYL IN SPINAL ANESTHESIA IN CESAREAN SECTION
Study Objective: Studying the efficacy of adding tramadol to spinal anesthesics for postoperative analgesia. Setting: This study was carried out in the department of anesthesia and reanimation at Alkark Hospital, during...