ALPHA – 1 ANTITRYPSIN IN SMOKERS AND NON SMOKERS CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 1
Abstract
Aim: The aim of the present study is to correlate and compare alpha-1 antitrypsin level in smoker and non smoker chronic obstructive pulmonary disease patients. Material and Methods: A comparative study was carried out in 200 subjects, more than 40 years of age and having chronic obstructive pulmonary disease for more than 1 year with a history of smoking at least 20 cigarettes per day (Group A) and without a history of smoking (Group B). Pulmonary function tests were used to diagnose the disease as per the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. Alpha-1 antitrypsin level was done by turbidimetry method on fully auto analyzer I-Lab 650 (Instrumentation Laboratory, USA) at Clinical Biochemistry Section, Laboratory Services Sir Takhtsinhji Hospital, Bhavnagar. Statistical analysis was done by using unpaired t-test and Pearson’s correlation coefficient. Results: Results of present study shows that alpha-1 antitrypsin level was decreased in smoker chronic obstructive pulmonary disease patients (150.83±18.853) when compared to non smokers (183.97±29.383). There was statistically significant difference in alpha-1 antitrypsin level between the two groups with ‘p’ value of <0.0001. Pearson’s correlation test show negative correlation between smoker and nonsmoker chronic obstructive pulmonary disease patients. Conclusion: The values of serum alpha-1 antitrypsin levels were more significantly decreased in smokers indicating an important role of smoking in pathogenesis of chronic obstructive pulmonary disease. Alpha-1 antitrypsin can act as a predictor for future development of chronic obstructive pulmonary disease in smokers and in nonsmokers.
Authors and Affiliations
Panchal Mittal A| Resident Doctor, Department of Biochemistry, Govt. Medical College, Bhavnagar, Gujarat, India, Corresponding author email: myth2911@ymail.com, Shaikh Sahema M| Tutor, Department of Biochemistry, Govt. Medical College, Bhavnagar, Gujarat, India, Sadariya Bhavesh R| Assistant Professor, Department of Biochemistry, Pacific Medical College, Bhiloka-bedla, Udaipur, Rajasthan, India, Bhoi Bharat K| Resident Doctor, Department of Biochemistry, Govt. Medical College, Bhavnagar, Gujarat, India, Sharma Hariom M| Professor and Head, Department of Biochemistry, Govt. Medical College, Bhavnagar, Gujarat, India
Keywords
Related Articles
- EP ID EP11340
- DOI 10.5958/2319-5886.2015.00006.5
- Views 301
- Downloads 12
Anybody Hear Us? Attempting to Meet the Psychological Care Needs of Older People: an Ethnographic Approach
Older people who live in residential settings need some psychological support because of vicissitudes of life they faced with. The aim of this study is to explore psychological care needs of older people in a residentia...
Effects of Two Sensory Stimulation Models on Recovery in Adults with Severe Traumatic Brain Injury
Background and Aims: Literature from medical and health sciences indicated that sensory stimulation had a positive effect on traumatic brain injury patients. The present study was aimed to fnd out the effectiveness of a...
Macroanatomy of the Azygos Vein: A Comparative Description between Human, Dog and Sheep
In this study, the macroanatomy of the azygos vein in the dog and sheep were compared to those of human. The obtained results showed that in dog it originates from cranial vena cava on the right side of thoracic cavity...
TIBIAL TORSION; DOES IT DIFFER IN CHILDREN WITH CONGENITAL TALIPES EQUINOVARUS (CTEV) COMPARED TO NORMAL ONES?
Background: Congenital talipes equinovarus (CTEV) or clubfoot is one of the commonest congenital orthopaedic conditions requiring intensive treatment. A typical clubfoot consists of a deformed foot in equinus ,varus,...
STUDY OF PRESCRIBING PATTERN OF ANTIMICROBIAL AGENTS IN AN IPD OF A TERTIARY CARE HOSPITAL IN AHMEDNAGAR
Objectives: To evaluate the pattern of use of Antimicrobial drugs in IPD patients admitted for various illnesses. Materials and Methods: It is a retrospective and observational study, conducted during the period of Janu...