ALPHA – 1 ANTITRYPSIN IN SMOKERS AND NON SMOKERS CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 1
Abstract
Aim: The aim of the present study is to correlate and compare alpha-1 antitrypsin level in smoker and non smoker chronic obstructive pulmonary disease patients. Material and Methods: A comparative study was carried out in 200 subjects, more than 40 years of age and having chronic obstructive pulmonary disease for more than 1 year with a history of smoking at least 20 cigarettes per day (Group A) and without a history of smoking (Group B). Pulmonary function tests were used to diagnose the disease as per the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. Alpha-1 antitrypsin level was done by turbidimetry method on fully auto analyzer I-Lab 650 (Instrumentation Laboratory, USA) at Clinical Biochemistry Section, Laboratory Services Sir Takhtsinhji Hospital, Bhavnagar. Statistical analysis was done by using unpaired t-test and Pearson’s correlation coefficient. Results: Results of present study shows that alpha-1 antitrypsin level was decreased in smoker chronic obstructive pulmonary disease patients (150.83±18.853) when compared to non smokers (183.97±29.383). There was statistically significant difference in alpha-1 antitrypsin level between the two groups with ‘p’ value of <0.0001. Pearson’s correlation test show negative correlation between smoker and nonsmoker chronic obstructive pulmonary disease patients. Conclusion: The values of serum alpha-1 antitrypsin levels were more significantly decreased in smokers indicating an important role of smoking in pathogenesis of chronic obstructive pulmonary disease. Alpha-1 antitrypsin can act as a predictor for future development of chronic obstructive pulmonary disease in smokers and in nonsmokers.
Authors and Affiliations
Panchal Mittal A| Resident Doctor, Department of Biochemistry, Govt. Medical College, Bhavnagar, Gujarat, India, Corresponding author email: myth2911@ymail.com, Shaikh Sahema M| Tutor, Department of Biochemistry, Govt. Medical College, Bhavnagar, Gujarat, India, Sadariya Bhavesh R| Assistant Professor, Department of Biochemistry, Pacific Medical College, Bhiloka-bedla, Udaipur, Rajasthan, India, Bhoi Bharat K| Resident Doctor, Department of Biochemistry, Govt. Medical College, Bhavnagar, Gujarat, India, Sharma Hariom M| Professor and Head, Department of Biochemistry, Govt. Medical College, Bhavnagar, Gujarat, India
Keywords
Related Articles
- EP ID EP11340
- DOI 10.5958/2319-5886.2015.00006.5
- Views 288
- Downloads 12
Pros and Cons of student marriage during study period among student in Yasuj University of Medical science, Iran
Because the student course is also the age and period of marriage and moreover the students are facing the important task of education which necessitates subjective and mental tranquility therefore the present research...
REGIONAL FACTORS RELATED WITH THE NUMBER OF AMBULANCE USERS
Introduction: Ambulance use was increasing along with growth population of aged in Japan. The purpose of study paper is to clarify the relationship between the state of healthcare service use as well as regional chara...
AN APPRAISAL OF REACTION TIME IN ELITE SPRINTERS AND ITS COMPARISON WITH AGE-MATCHED CONTROLS
Aim: Our study aimed to quantify sprinter’s reaction time and compared it with age-matched controls. Material methods: Database of 30 male sprinters and age-matched controls for reaction time (auditory, visual and wh...
Evaluation of Microbial Contamination of Mobile Phone among Dentists in College of Dentistry in Baghdad University
Background: Mobiles have become one of the most indispensable accessories of profession and social life. The mobiles make life easier, but they pose a number of new hazards also. Objectives: The principle aim of this st...
CASE OF CHOLEDOCHAL CYST PRESENTING AS PERFORATION ABDOMEN
Introduction: Choledochal cyst is an uncommon congenital anomaly of Hepoatobiliary system. It is a case of choledocal cyst presenting as perforation and biliary ascites which is rare in infants. Clinical picture: An in...