Alpha-glucosidase inhibitory effect and antioxidant properties of different extracts from Lycium barbarum L.

Journal Title: Journal of BioScience and Biotechnology - Year 2018, Vol 7, Issue 2

Abstract

Fruits of the plant Lycium barbarum L. (Goji berry) fruit have been widely used around the world for their medicinal purposes and as a functional food for more than 4500 years. Studies indicate the effects of the fruits of Goji berry on aging, neuroprotection, fatigue, energy expenditure, glucose control in diabetics, antioxidant properties, immunomodulation, anti-tumor activity, and cytoprotection. Some authors report that antioxidant molecules found in goji fruit might offer many health protective benefits by alleviating oxidative stress when used as an additive or in a mixture with other phytochemicals in fruit or herbal products. It was found that Goji berry fruit growing in Bulgaria has a total polysaccharide content of about 4%. The content of total polyphenol compounds in the different extracts was found to be between 5.5mg and 8mg GAE/g of dry product. Polyphenols from dry Goji berry fruit were extracted and studied by HPLC analysis for the type of polyphenols present. Antioxidant activity of extracts rich in polyphenols was determined by DPPH, FRAP and CUPRAC methods. The data was compared with a medicinal product containing an extract of Goji berry, where synergistic effects were also established. Inhibitory effects of the Goji berry extracts and their corresponding polyphenols were investigated in the presence of α-glucosidase for antidiabetic activity. The 50% inhibitory concentration found for organic extract was IC50=91.7 μg GAE/g of fruits. The study demonstrated that some of the polyphenols in the investigated extracts exhibit competitive properties towards the enzyme.

Authors and Affiliations

Mariana Nikolova, Alexander Aleksandrov, Ilia Iliev

Keywords

Related Articles

Efficacy of organic products against insect pests in alfalfa grown for seeds

Organic pesticides can be excellent alternatives to chemical pesticides. They occupy an important place in the plant protection sector. Evaluation of the efficacy was conducted using an alginate from seaweed (organic ins...

A review of Sphaeropsis sapinea occurrence on Pinus species in Bulgaria

Sphaeropsis sapinea (Fr.) Dyko & Sutton causes shoot blight and canker disease throughout the world on conifers predisposed by stress. The disease is most important to Pinus species that are affected from the seedling st...

 Chemical composition, in vitro gas production and energetic value of prickly pear fermented with and without Kluyveromyces marxianus

 The aim of this study was to characterize the chemical composition, in vitro gas production and energetic value of prickly pear during solid state fermentation (SSF) with Kluyveromyces marxianus. Prickly pear was i...

 Cloning and expression of gene encoding P23 protein from Cryptosporidium parvum

 We cloned the cp23 gene coding P23 (glyco)protein from Cryptosporidium parvum isolated from Thua Thien Hue province, Vietnam. The coding region of cp23 gene from C. parvum is 99% similar with cp23 gene deposited in...

 Genomic changes in speciation of the family Chironomidae, Diptera

 The mode of speciation adopted by a species or group of related species of animals (insects) is clearly determined to a certain extent by the architecture of their genetic system. Chromosome rearrangements, the loc...

Download PDF file
  • EP ID EP603338
  • DOI -
  • Views 89
  • Downloads 0

How To Cite

Mariana Nikolova, Alexander Aleksandrov, Ilia Iliev (2018). Alpha-glucosidase inhibitory effect and antioxidant properties of different extracts from Lycium barbarum L.. Journal of BioScience and Biotechnology, 7(2), 91-95. https://europub.co.uk/articles/-A-603338