ALPORT SYNDROME – A RARE KIDNEY DISEASE OF DOMESTIC DOG CANIS LUPUS FAMILIARIS
Journal Title: Folia Pomeranae Universitatis Technologiae Stetinensis Agricultura Alimentaria Piscaria et Zootechnica - Year 2016, Vol 40, Issue 330
Abstract
Alport syndrome is a rare, hereditary renal disease which is the result of a lack of one chain of type IV collagen (α3, α4, and α5). Type IV collagen is a basic structural component of the glomerular basement membrane. Alport syndrome has been reported in humans, mice and domestic dogs. Mutations in COL4A3 and COL4A4 genes are both of recessive and dominant type; however, the most common mutations in COLL4A5 gene are linked to X sex chromosome. These mutations render the synthesis of (α3, α4, α5) chain impossible, thus the resulting type IV collagen does not have its proper structure and filtration of plasma is impaired, leading to progressive renal insufficiency and failure. With the current state of medical knowledge the only therapy, delaying the pathological processes, is limited to dialysis and kidney transplantation. This paper presents information on symptoms of Alport syndrome, as well as genetic basis and molecular effects of mutations causing the disease. It also offers dog breeders some advice, based on the available literature, in order to facilitate making the right breeding decisions.
Authors and Affiliations
Agata KANIA, Joanna GRUSZCZYŃSKA, Bartłomiej J. BARTYZEL, Beata GRZEGRZÓŁKA, Małgorzata MIKUŁA
Keywords
Related Articles
- EP ID EP411788
- DOI -
- Views 74
- Downloads 0
SEASONAL CHANGES IN OCCURRENCE OF Fusarium ISOLATES IN GRAIN WAREHOUSES
Cereal grains on global scale provide more energy than other types of crops. They are a rich in carbohydrates and are the main source of this nutritional substances. Cereal and products made of it supply half of daily ca...
THE INFLUENCE OF SOIL DIFFERENTIATION ON CHEMICAL COMPOSITION OF SEA BUCKTHORN (HIPPOPHAË RHAMNOIDES L.) LEAVES AS FEED MATERIAL
Due to the fact that sea buckthorn leaves could be a supplement to animal feed and food products, the present research aimed at determining the content of such elements as nitrogen, phosphorus, potassium, calcium, magnes...
FEASIBILITY OF USING Festuca arundinacea FOR REGENERATION OF GRASSLANDS BY MEANS OF FULL CULTIVATION METHOD ON ORGANIC SOIL
The study was carried out in the Randow river valley, on grassland belonging to the farm – Raminer Agrar GmbH & Co (Germany). Restoration of grassland located on organic soil, was carried out using the full cultivation m...
DEPENDENCIES BETWEEN PRL GENE POLYMORPHISM AND PRODUCTION PROGRESS IN POLISH HOLSTEIN-FRIESIAN BLACK-AND-WHITE COWS
The aim of this study was to analyse dependencies between PRL gene polymorphism within exon 4 of bovine chromosome 23 (locus g.8398G>A), and the level of production progress in milk yield, yields of milk fat and milk pro...
ANALYSIS OF THE EFFECT OF THE ORDER OF CALVING, CALF SEX AND MILK YIELD OF COWS ON GROWTH PARAMETERS OF LIMOUSIN CALVES
The study was taken in the farm located in West Pomerania province where Limousine cattle in purity of breed were kept. The study included a total of 226 Limousine calves in purity of breed, which were born between 2011...