ALTERATION IN THE ACTIVITY OF OXIDATIVE ENZYMES IN THE TISSUES OF MALE WISTAR ALBINO RATS EXPOSED TO CADMIUM

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ALTERATION IN THE ACTIVITY OF OXIDATIVE ENZYMES IN THE TISSUES OF MALE WISTAR ALBINO RATS EXPOSED TO CADMIUM

Journal Title: International Journal of Occupational Medicine and Environmental Health - Year 2010, Vol 23, Issue 1

Abstract

[b]Objective:[/b] The objective of the present study was to investigate the effect of cadmium (Cd) on the activities of some oxidative enzymes [viz Aldehyde oxidase, AO (E.C. 1.2.3.1); Xanthine oxidase, XO (E.C. 1.2.3.2); Sulphite oxidase, SO (E.C.1.8.3.1.); and Monoamine oxidase, MO (E.C. 1.4.3.4)] in the liver and kidney. [b]Materials and methods:[/b] Male Wistar albino rats were administered 1, 2 and 4 mg Cd2+/kg body weight for one and three months. The activities of the oxidative enzymes were subsequently analyzed in the liver and kidney after both periods of exposure. [b]Results:[/b] There was a dose dependent increase in liver and kidney Cd concentration in the test rats as compared to control after both periods of treatment with the liver retaining higher concentration of Cd than the kidney for each of the exposure dose. The oxidative enzymes were decreased in a dose dependent manner in the liver and kidney after both periods of treatment. The percentage inhibition of these enzymes was less in the liver of rats treated with Cd for three months relative to the one month treated rats for each of the exposure dose. Conversely, the inhibition of the activities of these enzymes in the kidney of rats in all the treatment groups was more pronounced after three months relative to the trend in the one month treated rats. However, the activities of the oxidative enzymes were higher in the liver as compared to the kidney in all the treatment groups after both durations of Cd treatment. [b]Conclusion:[/b] Based on the results obtained, it can be concluded that the inhibition of the oxidative enzymes by Cd may disturb metabolism of bioactive endogenous substances, exogenous components of food and some xenobiotics.

Authors and Affiliations

SAMUEL ASAGBA

Keywords

RESIDENTIAL PROXIMITY TO ENVIRONMENTAL SOURCES OF PERSISTENT ORGANIC POLLUTANTS

[b]Objectives:[/b] Environmental exposure to persistent organic pollutants (POPs) has been associated with an increased risk of both acute myocardial infarction (AMI) and diabetes mellitus (DM). A study of first-time hos...

Authors’ response (December 8, 2017) to the letter to the Editor concerning the paper “Occupational exposure to radon for underground tourist routes in Poland: Doses to lung and the risk of developing lung cancer”

Refers to: Mortazavi JSM, Bevelacqua JJ, Fornalski KW, Pennington CW, Welsh J, Janiak MK, et al. Letter to the editor (August 24, 2017) concerning the paper “Occupational exposure to radon for underground tourist routes...

EP ID EP134257
DOI DOI 10.2478/v10001-010-0002-y
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