Alteration of Corneal Structure in Patients with Diabetes Mellitus
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 8
Abstract
Objective: To determine the alteration in corneal characteristics such as endothelial cell density, mean cell area, coefficient of variation in cell size, hexagonality percentage and central corneal thickness in diabetic patients by comparing with a non diabetic group in a tertiary care hospital in South India Methods: A cross sectional study was done including 190 diabetic patients and 190 non diabetic subjects in the age group of 40-70 years enrolled over a period of 1 year. Demographic data was collected and specular microscopy and pachymetry was done for all the subjects. The corneal parameters were compared in the 2 groups using independent samples t test. Results: The mean age in the diabetic group was 57.91 and non diabetic group was 56.09. The mean values of mean cell area (437.17±134.32 and 394.11±143.68) coefficient of variation in cell size (28.02±9.94 and 22.68±6.09) were significantly higher in diabetic group compared to the non diabetic group. Hexagonality percentage was significantly lower in the diabetic group (55.46±19.65) compared to non diabetic group (75.94±6.48). Among the diabetic population, duration of diabetes had significant correlation with central corneal thickness (r=+0.190) and HbA1c levels had significant negative correlation with endothelial cell density and hexagonality (r=-0.318 and r=-0.239 respectively). Conclusions: Endothelial cell morphology was found to be altered in patients with diabetes compared to non diabetic subjects which was associated with duration of disease and glycemic control in diabetic patients. This may have implications in the careful selection and intraoperative precautions in patients undergoing intraocular procedures.
Authors and Affiliations
Chitra Raghavan
Keywords
Related Articles
- EP ID EP529829
- DOI -
- Views 77
- Downloads 0
Atherogenic Indices as Markers for Risk of Myocardial Infarction in Obese
The rising prevalence of obesity in India has a direct correlation with the increasing prevalence of obesity-related co-morbidities; hypertension, the metabolic syndrome, dyslipidemia, type 2 diabetes mellitus (T2DM), an...
Comparison Between Inhibitive Distraction and Intermittent Cervical Traction on Pain and Disability in Patient’s With Non-Specific Neck Pain
Aim: Aim of this study is to assess and compare the effect of cervical traction or inhibitive distraction on pain and disability in Patient with non-specific neck pain. Methodology: 27 Patients were randomly selected fro...
Rheumatological Manifestations in Diabetic Population in a Tertiary Care Hospital
Rheumatological disorders in the patient of diabetes are very common still these are neglected. This was an observational, prospective hospital based study conducted on 200 diabetic patients from IGIMS OPD, Department of...
Outcome of Pregnancy in Elderly Primigravida
Background: In India, the average age of marriage is 20-23 years and majority of women complete their families by the first half of their twenties. With improved health and education, increasing number of women in our st...
No Suture No Glue Technique of Scleral Fixated IOL (SFIOL) Implantation for Management of Aphakia
Purpose: To report results of a new technique for sutureless glueless intrascleral fixation of three piece posterior chamber intraocular lens (IOL) using 26-gauge needle for management of aphakia. Design: Prospective, no...